Trial reportThorax2004
Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials.
Trial report in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effects of different treatments on metabolic syndrome in patients with obstructive sleep apnea: a meta-analysis.Frontiers in medicine · 2024Pooled it
- Association between elevated homocysteine levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Soluble P-selectin levels in patients with obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Pooled it
- Beneficial effect of continuous positive airway pressure on lipid profiles in obstructive sleep apnea: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2015Pooled it
- Effect of continuous positive airway pressure on homocysteine levels in patients with obstructive sleep apnea: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2014Pooled it
- Continuous positive airways pressure for obstructive sleep apnoea in adults.The Cochrane database of systematic reviews · 2006Pooled it
- The effect of acute aerobic exercise on hemostasis in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2017Trial
- Effect of continuous positive airway pressure on day/night rhythm of prothrombotic markers in obstructive sleep apnea.Sleep medicine · 2013Trial
- Association between sleep apnea severity and blood coagulability: Treatment effects of nasal continuous positive airway pressure.Sleep & breathing = Schlaf & Atmung · 2006Trial
- Trial
- Sleep apnea increases odds of 90-day postoperative complications and healthcare utilization following lumbar discectomy.North American Spine Society journal · 2025Article
- A novel diastolic dysfunction score: A proposed diagnostic predictor for left ventricular dysfunction in obese population.Narra J · 2025Article
- Risk factors for pulmonary embolism: a case-control study.Journal of thoracic disease · 2025Article
- The Recurrence of Venous Thromboembolism in Obstructive Sleep Apnea: A Narrative Review.Canadian respiratory journal · 2025Review
- The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.Thrombosis and haemostasis · 2024Article
- Non-Linear Association between Obstructive Sleep Apnea Risk and Lipid Profile: Data from the 2015-2018 National Health and Nutrition Examination Survey.Reviews in cardiovascular medicine · 2024Article
- Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options.Translational stroke research · 2024Review
- Prevalence of dyslipidaemia in OSA patients at a tertiary care center.American journal of cardiovascular disease · 2023Article
- Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea.Frontiers in neurology · 2023Article
- Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.Biomedicines · 2022Review
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnoea (OSA) is associated with high cardiovascular morbidity and mortality and is an independent risk factor for hypertension. Novel circulating cardiovascular risk markers enabling a more accurate prediction of cardiovascular risk have been identified. Examination of these markers may clarify the increased risk in OSA and contribute to an analysis of the benefits of treatment.
methodsPlasma levels of total cholesterol and triglyceride and activated coagulation factors XIIa and VIIa, factors VII, VIII, XII, fibrinogen, thrombin-antithrombin (TAT), von Willebrand factor antigen (vWFAg), soluble P-selectin (sP-sel), and homocysteine were measured before and after treatment for 1 month with therapeutic or subtherapeutic (control) continuous positive airways pressure (CPAP) in 220 patients with OSA.
resultsLevels of activated coagulation factors XIIa, VIIa, TAT and sP-sel were higher in OSA patients at baseline than in unmatched controls, but did not fall with 1 month of therapeutic CPAP treatment. The raised sP-sel levels correlated only with body mass index (p = 0.002). There was a trend towards a significant fall in total cholesterol with therapeutic CPAP (p = 0.06) compared with the control group. In the therapeutic group there was a clinically significant mean fall in total cholesterol of 0.28 mmol/l (95% confidence interval 0.11 to 0.45, p = 0.001) which may reduce cardiovascular risk by about 15%.
conclusionA number of activated coagulation factors are increased in untreated OSA patients, potentially contributing to vascular risk, but they do not fall with 1 month of CPAP treatment. Nasal CPAP may produce a clinically relevant fall in total cholesterol level, potentially reducing cardiovascular risk, but this needs to be verified in a larger prospective study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.