ArticleThorax2004
Antitussive activity of iodo-resiniferatoxin in guinea pigs.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 113 citations in OpenAlex.
- Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough.Respiratory research · 2019Trial
- TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2023Review
- Article
- Advances in TRP channel drug discovery: from target validation to clinical studies.Nature reviews. Drug discovery · 2022Review
- Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation.Frontiers in immunology · 2020Review
- Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Non-astmatic Eosinophilic Bronchitis.Turkish thoracic journal · 2018Review
- The emerging role of transient receptor potential channels in chronic lung disease.The European respiratory journal · 2017Review
- Role of reactive oxygen species and TRP channels in the cough reflex.Cell calcium · 2016Review
- Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.The Journal of pharmacology and experimental therapeutics · 2016Article
- Article
- Oxidative stress as activators of sensory nerves for cough.Pulmonary pharmacology & therapeutics · 2015Review
- Peripheral neural circuitry in cough.Current opinion in pharmacology · 2015Review
- Targeting TRP channels for chronic cough: from bench to bedside.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- Article
- Transient receptor potential (TRP) channels in the airway: role in airway disease.British journal of pharmacology · 2014Review
- TRPs in taste and chemesthesis.Handbook of experimental pharmacology · 2014Review
- Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels.Pulmonary pharmacology & therapeutics · 2013Review
- The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Unravelling the mystery of capsaicin: a tool to understand and treat pain.Pharmacological reviews · 2012Review
Corrections and comments
- Commented on byTRPV1 and cough.2004
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent antagonist of the transient receptor potential vanilloid-1 (TRPV1).
methodsThe ability of I-RTX to inhibit cough induced by inhalation of two putative TRPV1 stimulants (capsaicin and citric acid) was tested in non-anaesthetised guinea pigs.
resultsPretreatment with I-RTX either intraperitoneally (0.03-0.3 micromol/kg) or by aerosol (0.1-3 microM) reduced the number of coughs produced by inhalation of citric acid (0.25 M) and capsaicin (30 microM) in a dose dependent manner. Capsazepine (CPZ) also reduced citric acid and capsaicin induced cough, but the activity of I-RTX was 10-100 times more potent than CPZ in all the experimental conditions tested.
conclusionsI-RTX is a novel and potent antitussive drug which inhibits cough mediated by agents possibly acting via TRPV1 activation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.