ArticleJournal of clinical pathology2004
Relation between lymphopenia and bacteraemia in UK adults with medical emergencies.
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis.The Journal of infection · 2019Pooled it
- Delta neutrophil index (DNI) as a novel diagnostic and prognostic marker of infection: a systematic review and meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Pooled it
- Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients.Infection · 2026Article
- Lymphopenia in sepsis: a narrative review.Critical care (London, England) · 2024Review
- Neutrophil-to-lymphocyte ratio in community-acquired pneumonia: Diagnostic potential and its limitations in the COVID era.Journal of family medicine and primary care · 2024Article
- Blood neutrophil to lymphocyte ratio is associated with 90-day mortality and 60-day readmission in Gram negative bacteremia: a multi-center cohort study.BMC infectious diseases · 2024Article
- A novel nomogram integrating body composition and inflammatory-nutritional markers for predicting postoperative complications in patients with adhesive small bowel obstruction.Frontiers in nutrition · 2024Article
- Bat cellular immunity varies by year and dietary habit amidst land conversion.Conservation physiology · 2024Article
- Analysis of factors influencing bronchiectasis patients with active pulmonary tuberculosis and development of a nomogram prediction model.Frontiers in medicine · 2024Article
- Hematologic Parameters as Predictors of Long-Term Mortality in Infective Endocarditis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Novel Hematological Parameters in the Assessment of the Extent of Cardiac Implantable Electronic Device-Related Infections.Journal of clinical medicine · 2023Article
- Article
- Accuracy of C-reactive protein and a differentiated white cell count in diagnosing tuberculosis.Southern African journal of infectious diseases · 2023Article
- Role of Biomarkers in Periprosthetic Joint Infections.Diagnostics (Basel, Switzerland) · 2022Review
- The role of neutrophil-to-lymphocyte ratio in predicting disease progression and emergency surgery indication in benign intestinal obstructions.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Diagnostic accuracy of quick SOFA score and inflammatory biomarkers for predicting community-onset bacteremia.Scientific reports · 2022Article
- Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections.Biomedicines · 2021Review
- Efficacy of grape seed hydro-alcoholic extract in the treatment of experimentally Pasteurella multocida infected rabbits.Veterinary medicine and science · 2021Article
- The Predictive Value of Interleukin-6 and Neutrophil-Lymphocyte Ratio in Patients with Severe and Extremely Severe Oral and Maxillofacial Space Infections.BioMed research international · 2021Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia. PATIENTS/
methodsA two year cohort study carried out in a teaching hospital in Oxford, UK of 21,495 consecutive adult emergency admissions to general medical or infectious disease wards. Full blood data were available in 21,372 cases; 41 cases with extreme full blood count results (neutrophil count, > 75 x 10(9)/litre; lymphocyte count, > 10 x 10(9)/litre) were excluded, leaving 21,331 cases for analysis. The association between the admission lymphocyte and neutrophil counts and the risk of bacteraemia was assessed.
resultsNeutrophilia and lymphopenia were both associated with bacteraemia. Lymphopenia was the better predictor in this cohort. Both neutrophilia and lymphopenia were more predictive of bacteraemia than the total white blood cell count.
conclusionsBoth lymphocyte and neutrophil counts, rather than total white blood cell count, should be considered in adult medical admissions with suspected bacteraemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.