ArticleJournal of clinical pathology2004
Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer.
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Matricellular Proteins in Bladder Cancer: Context-Dependent Roles in Tumor Promotion and Suppression.International journal of molecular sciences · 2026Review
- Usability Evaluation of Urinary HAI-1, STMN-1 and TN-C in the Diagnosis of Bladder Cancer.Journal of clinical medicine · 2025Article
- The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy.International journal of molecular sciences · 2023Review
- What is new in cancer-associated fibroblast biomarkers?Cell communication and signaling : CCS · 2023Review
- Tumorigenic effects of human mesenchymal stromal cells and fibroblasts on bladder cancer cells.Frontiers in oncology · 2023Article
- The dynamic roles of the bladder tumour microenvironment.Nature reviews. Urology · 2022Review
- Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer.British journal of cancer · 2021Article
- Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups.British journal of cancer · 2017Article
- The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer.Diagnostic pathology · 2015Article
- Tenascin-C and carcinoma cell invasion in oral and urinary bladder cancer.Cell adhesion & migration · 2015Review
- Priming cancer cells for drug resistance: role of the fibroblast niche.Frontiers in biology · 2014Article
- Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis.British journal of cancer · 2013Review
- The role of the tumor microenvironment in regulating angiogenesis.Cold Spring Harbor perspectives in medicine · 2012Article
- Significance of plasma osteopontin levels in patients with bladder urothelial carcinomas.Molecular diagnosis & therapy · 2012Article
- Stromal LRP1 in lung adenocarcinoma predicts clinical outcome.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- A migration signature and plasma biomarker panel for pancreatic adenocarcinoma.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- B and C domain containing tenascin-C: urinary markers for invasiveness of urothelial carcinoma of the urinary bladder?Journal of cancer research and clinical oncology · 2009Article
- Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue.Cancer science · 2009Article
- Tenascin C in medullary thyroid microcarcinoma and C-cell hyperplasia.Virchows Archiv : an international journal of pathology · 2009Article
- The role of structural extracellular matrix proteins in urothelial bladder cancer (review).Biomarker insights · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTenascin-C (Tn-C) is an extracellular matrix glycoprotein that is upregulated in malignant tumours. Tn-C promotes cell growth, cell migration, and angiogenesis. It has been suggested to be a prognostic factor in various types of malignant tumours, but there is little information on its significance in bladder cancer with regard to overall survival (OS) and recurrence free survival (RFS).
methodsTn-C expression was studied in 106 patients with bladder cancer diagnosed between 1994 and 1997. Immunohistochemistry was performed using a monoclonal antibody against Tn-C. RFS and OS were estimated by the Kaplan-Meier method and compared by the log rank test in univariate analysis and by the Cox multistep regression method in multivariate analysis.
resultsWithin the mean follow up period of 126 months, patients with diffuse Tn-C staining in the tumour stroma had a significantly worse OS than those with negative staining or only moderate Tn-C expression (p = 0.025). Patients with cytoplasmic expression of Tn-C had a significantly better OS than those without (p = 0.001). Multivariate analysis, taking into consideration age, grade, stage, tumour associated carcinoma in situ, progression, and Tn-C staining in tumour stroma, showed that only expression of Tn-C in invasive tumour cells was an independent positive prognostic factor for OS (p = 0.049).
conclusionsTn-C may provide important prognostic information in bladder cancer depending on the expression pattern in the tumour stroma or cytoplasm of the tumour cells.
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