ArticleJournal of neuro-oncology2004
Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas.
Article in Journal of neuro-oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Histologic grade and extent of resection are associated with survival in pediatric spinal cord ependymomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Pooled it
- SIOP Ependymoma I: Final results, long-term follow-up, and molecular analysis of the trial cohort-A BIOMECA Consortium Study.Neuro-oncology · 2022Trial
- Intracranial ependymomas treated with radiotherapy: long-term results from a single institution.Journal of neuro-oncology · 2011Trial
- Treatment Outcomes of Patients with Ependymoma Receiving Radiotherapy: A Single Institution Experience.Oncology · 2024Article
- Patterns of relapse for children with localized intracranial ependymoma.Journal of neuro-oncology · 2018Article
- Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.Journal of neuro-oncology · 2017Article
- Region Specific Differences of Claudin-5 Expression in Pediatric Intracranial Ependymomas: Potential Prognostic Role in Supratentorial Cases.Pathology oncology research : POR · 2017Article
- Understanding Ependymoma Oncogenesis: an Update on Recent Molecular Advances and Current Perspectives.Molecular neurobiology · 2017Review
- Pencil beam scanning proton therapy for pediatric intracranial ependymoma.Journal of neuro-oncology · 2016Article
- Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients.Neuro-oncology · 2013Article
- Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology.Journal of neuro-oncology · 2012Article
- Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy.Journal of neuro-oncology · 2012Article
- Pediatric anaplastic parenchymal ependymoma: case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Recurrent pituitary ependymoma: a complex clinical problem.Pituitary · 2010Article
- Surgical management of supratentorial ependymomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Review
- Survival following treatment for intracranial ependymoma: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Review
- Three-dimensional conformal radiation therapy for ependymoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Classification and controversies in pathology of ependymomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Review
- Outcome of teenagers and young adults with ependymoma: the Royal Marsden experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2009Article
- Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study.The Lancet. Oncology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were anaplastic. Complete resection was performed in 18 patients, incomplete resection in 19, and stereotactic biopsy in 6. Radiotherapy was done in 31 patients and chemotherapy in 13. The surviving patients have been followed 8-232 months (median: 69 months). The median survival time was 30 months, and 5-year overall survival and progression-free survival rates were 53.9% and 45.9%, respectively. By tumor site: supratentorial, 56.6% and 50.9%; infratentorial, 52.3% and 42.5%. Multivariate analysis identified complete resection (5-year progression-free survival, 71.8%) and age <3 years old as significant favorable and adverse prognostic features (relative risk, 2.59; 95% CI, 1.05-6.38), respectively. Twenty-six children relapsed 1-107 months after diagnosis (median: 12 months). Relapses were local in 22 cases, and combined local and distant in three cases. Only one of 15 patients with supratentorial tumors developed isolated spinal metastasis. Failure at the primary site is the major obstacle to improve cure rates. The extent of surgical resection and age were the only statistically significant prognostic factors.
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