ArticleProceedings of the National Academy of Sciences of the United States of America2004
Intracellular actin-based transport: how far you go depends on how often you switch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 86 citations in OpenAlex.
- Molecular underpinnings of cytoskeletal cross-talk.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Heterogeneities Shape Passive Intracellular Transport.Biophysical journal · 2019Article
- Myosin Va transport of liposomes in three-dimensional actin networks is modulated by actin filament density, position, and polarity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Viscoelasticity Measurements Reveal Rheological Differences Between Stem-like and Non-stem-like Breast Cancer Cells.Cellular and molecular bioengineering · 2017Article
- Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles.Biophysical journal · 2016Article
- Cytoskeletal Network Morphology Regulates Intracellular Transport Dynamics.Biophysical journal · 2015Article
- A physical perspective on cytoplasmic streaming.Interface focus · 2015Article
- Calibration of optical tweezers for in vivo force measurements: how do different approaches compare?Biophysical journal · 2014Article
- Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- Intracellular transport of insulin granules is a subordinated random walk.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Filament-filament switching can be regulated by separation between filaments together with cargo motor number.PloS one · 2013Article
- Dynamic actin gene family evolution in primates.BioMed research international · 2013Article
- Turing's next steps: the mechanochemical basis of morphogenesis.Nature reviews. Molecular cell biology · 2011Review
- How molecular motors are arranged on a cargo is important for vesicular transport.PLoS computational biology · 2011Article
- Principles of unconventional myosin function and targeting.Annual review of cell and developmental biology · 2011Review
- Probabilistic density maps to study global endomembrane organization.Nature methods · 2010Article
- Rule-based spatial modeling with diffusing, geometrically constrained molecules.BMC bioinformatics · 2010Article
- Bidirectional transport by molecular motors: enhanced processivity and response to external forces.Biophysical journal · 2010Article
- Motor number controls cargo switching at actin-microtubule intersections in vitro.Current biology : CB · 2010Article
- Mechanochemical model for myosin V.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Intracellular molecular motor-driven transport is essential for such diverse processes as mitosis, neuronal function, and mitochondrial transport. Whereas there have been in vitro studies of how motors function at the single-molecule level, and in vivo studies of the structure of filamentary networks, studies of how the motors effectively use the networks for transportation have been lacking. We investigate how the combined system of myosin-V motors plus actin filaments is used to transport pigment granules in Xenopus melanophores. Experimentally, we characterize both the actin filament network, and how this transport is altered in response to external signals. We then develop a theoretical formalism to explain these changes. We show that cells regulate transport by controlling how often granules switch from one filament to another, rather than by altering individual motor activity at the single-molecule level, or by relying on structural changes in the network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.