ArticleJournal of virology2004
Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Blood Group Antigen Combinations and COVID-19: Complexity, Associations and Possible Clinical Relevance.Life (Basel, Switzerland) · 2026Article
- Atomic force microscopy at the forefront: unveiling foodborne viruses with biophysical tools.Npj viruses · 2025Review
- Hepatitis A virus infection.Nature reviews. Disease primers · 2023Review
- A large-scale genetic correlation scan between rheumatoid arthritis and human plasma protein.Bone & joint research · 2022Article
- Pathogenicity and virulence of hepatitis A virus.Virulence · 2021Review
- Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.Nature microbiology · 2020Article
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- CD71mBio · 2019Article
- Hepatitis A Virus Capsid Structure.Cold Spring Harbor perspectives in medicine · 2019Review
- Evidence for positive selection of hepatitis A virus antigenic variants in vaccinated men-having-sex-with men patients: Implications for immunization policies.EBioMedicine · 2019Article
- Complex signatures of natural selection at GYPA.Human genetics · 2018Article
- Hepatitis A virus genotype distribution during a decade of universal vaccination of preadolescents.International journal of molecular sciences · 2015Article
- Molecular basis of the behavior of hepatitis a virus exposed to high hydrostatic pressure.Applied and environmental microbiology · 2014Article
- Article
- Molecular biology and inhibitors of hepatitis A virus.Medicinal research reviews · 2014Review
- Hepatitis A virus adaptation to cellular shutoff is driven by dynamic adjustments of codon usage and results in the selection of populations with altered capsids.Journal of virology · 2014Article
- Development of lectin-linked immunomagnetic separation for the detection of hepatitis a virus.Viruses · 2014Article
- Population genomic analysis reveals a rich speciation and demographic history of orang-utans (Pongo pygmaeus and Pongo abelii).PloS one · 2013Article
- A single mutation in the glycophorin A binding site of hepatitis A virus enhances virus clearance from the blood and results in a lower fitness variant.Journal of virology · 2012Article
- Hepatitis a virus vaccine escape variants and potential new serotype emergence.Emerging infectious diseases · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis A virus (HAV) has previously been reported to agglutinate human red blood cells at acidic pHs. Treatment of erythrocytes with different enzymes and chemical reagents indicated that HAV attachment is mediated through an interaction with sialylglycoproteins. HAV hemagglutination could be blocked by incubating the virus with glycophorin A, indicating that this sialylglycoprotein is the erythrocyte receptor. The number of receptors used was estimated to be around 500 per cell. At the same time, HAV-induced hemagglutination could also be blocked by either monoclonal antibody H7C27 or an anti-VP3(102-121) ascitic fluid, indicating that lysine 221 of VP1 and the surrounding VP3 residues lining the capsid pit are involved in HAV binding to erythrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.