ArticleThe Journal of physiology2004
Neuroepithelial oxygen chemoreceptors of the zebrafish gill.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 216 citations in OpenAlex.
- Article
- Specialized gas-exchange endothelium of the zebrafish gill.bioRxiv : the preprint server for biology · 2025Article
- Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill.The Journal of physiology · 2025Article
- Serotonin Signaling and Macrophage Subsets in Goldfish Gills: Unraveling the Neuroimmune Network for Gill Homeostasis.Life (Basel, Switzerland) · 2025Article
- Oxygen chemoreceptor inhibition by dopamine DThe Journal of physiology · 2025Article
- Structure and function of the larval teleost fish gill.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Gulf toadfish (Opsanus beta) gill neuroepithelial cells in response to hypoxia exposure.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Identification of signalling pathways involved in gill regeneration in zebrafish.The Journal of experimental biology · 2024Article
- A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance.International journal of molecular sciences · 2023Review
- Insights into the control and consequences of breathing adjustments in fishes-from larvae to adults.Frontiers in physiology · 2023Review
- Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia.Scientific reports · 2022Article
- Shaping the cardiac response to hypoxia: NO and its partners in teleost fish.Current research in physiology · 2022Article
- Fish Behavior as a Neural Proxy to Reveal Physiological States.Frontiers in physiology · 2022Review
- Neurochemical Signalling Associated With Gill Oxygen Sensing and Ventilation: A Receptor Focused Mini-Review.Frontiers in physiology · 2022Review
- The development of the OJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Comparative morphological and molecular studies on the oxygen-chemoreceptive cells in the carotid body and fish gills.Cell and tissue research · 2021Review
- Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Hydrogen sulphide sensitivity and tolerance in genetically distinct lineages of a selfing mangrove fish (Kryptolebias marmoratus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- The role of TASK-2 channels in COAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Hypoxia attenuate ionic transport in the isolated gill epithelium of Carcinus maenas.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In aquatic vertebrates, hypoxia induces physiological changes that arise principally from O(2) chemoreceptors of the gill. Neuroepithelial cells (NECs) of the zebrafish gill are morphologically similar to mammalian O(2) chemoreceptors (e.g. carotid body), suggesting that they may play a role in initiating the hypoxia response in fish. We describe morphological changes of zebrafish gill NECs following in vivo exposure to chronic hypoxia, and characterize the cellular mechanisms of O(2) sensing in isolated NECs using patch-clamp electrophysiology. Confocal immunofluorescence studies indicated that chronic hypoxia (P(O(2)) = 35 mmHg, 60 days) induced hypertrophy, proliferation and process extension in NECs immunoreactive for serotonin or synaptic vesicle protein (SV2). Under voltage clamp, NECs responded to hypoxia (P(O(2)) = 25-140 mmHg) with a dose-dependent decrease in K(+) current. The current-voltage relationship of the O(2)-sensitive current (I(KO(2))) reversed near E(K) and displayed open rectification. Pharmacological characterization indicated that I(KO(2)) was resistant to 20 mM tetraethylammonium (TEA) and 5 mM 4-aminopyridine (4-AP), but was sensitive to 1 mm quinidine. In current-clamp recordings, hypoxia produced membrane depolarization associated with a conductance decrease; this depolarization was blocked by quinidine, but was insensitive to TEA and 4-AP. These biophysical and pharmacological characteristics suggest that hypoxia sensing in zebrafish gill NECs is mediated by inhibition of a background K(+) conductance, which generates a receptor potential necessary for neurosecretion and activation of sensory pathways in the gill. This appears to be a fundamental mechanism of O(2) sensing that arose early in vertebrate evolution, and was adopted later in mammalian O(2) chemoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.