ArticleThe Journal of physiology2004
A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cells.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 133 citations in OpenAlex.
- Review
- Aging Alters Hair Cell Physiological Properties in Mice With Late-Onset Age-Related Hearing Loss.Aging cell · 2026Article
- Modeling developmental spiking behavior driven by ionic current dynamics of mouse and human inner hair cells using a calcium-enhanced Izhikevich framework.Journal of computational neuroscience · 2026Article
- Spontaneous Calcium Signalling in the Developing Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms driving the functional maturation of the developing mammalian auditory pathway.Current topics in developmental biology · 2025Review
- In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells.JCI insight · 2024Article
- Article
- Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.Trends in neurosciences · 2024Review
- A critical period of prehearing spontaneous CaThe EMBO journal · 2023Article
- Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells.PloS one · 2022Article
- Review
- Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals.G3 (Bethesda, Md.) · 2021Article
- MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates CaThe Journal of physiology · 2021Article
- SK Current, Expressed During the Development and Regeneration of Chick Hair Cells, Contributes to the Patterning of Spontaneous Action Potentials.Frontiers in cellular neuroscience · 2021Article
- Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea.The Journal of physiology · 2021Article
- Purinergic Modulation of Activity in the Developing Auditory Pathway.Neuroscience bulletin · 2020Review
- Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells.The Journal of physiology · 2020Article
- Distribution and Functional Characteristics of Voltage-Gated Sodium Channels in Immature Cochlear Hair Cells.Neuroscience bulletin · 2020Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From just after birth, mouse inner hair cells (IHCs) expressed a Ca(2+)-activated K(+) current that was reduced by intracellular BAPTA at concentrations >or= 1 mM. The block of this current by nifedipine suggests the direct involvement of Ca(v)1.3 Ca(2+) channels in its activation. On the basis of its high sensitivity to apamin (K(D) 360 pM) it was identified as a small-conductance Ca(2+)-activated K(+) current (SK), probably SK2. A similar current was also found in outer hair cells (OHCs) from the beginning of the second postnatal week. In both cell types the appearance of the SK current coincided with their becoming responsive to acetylcholine (ACh), the main efferent neurotransmitter in the cochlea. The effect of ACh on IHCs was abolished when they were simultaneously superfused with strychnine, consistent with the presence of nicotinic ACh receptors (nAChRs). Extracellular Ca(2+) either potentiated or blocked the nAChR current depending on its concentration, as previously reported for the recombinant alpha9alpha10 nAChR. Outward currents activated by ACh were reduced by blocking the SK current with apamin or by preventing SK current activation with intracellular BAPTA (>or= 10 mM). The endogenous mobile Ca(2+) buffer concentration was estimated to be equivalent to about 1 mM BAPTA, suggesting that in physiological conditions the SK channel is significantly activated by Ca(2+) influx through both Ca(v)1.3 Ca(2+) channels and alpha9alpha10 nAChRs. Current clamp experiments showed that in IHCs the SK current is required for sustaining a train of action potentials and also modulates their frequency when activated by ACh.
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