ArticleJournal of neurophysiology2005
Membrane bistability in thalamic reticular neurons during spindle oscillations.
Article in Journal of neurophysiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 101 citations in OpenAlex.
- Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep.Software impacts · 2024Article
- Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome.Cell reports · 2024Article
- Voltage-Seq: all-optical postsynaptic connectome-guided single-cell transcriptomics.Nature methods · 2023Article
- Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets.Neurobiology of disease · 2023Review
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- Article
- A role for spindles in the onset of rapid eye movement sleep.Nature communications · 2020Article
- TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- How Sleep Shapes Thalamocortical Circuit Function in the Visual System.Annual review of vision science · 2019Review
- Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat.Frontiers in integrative neuroscience · 2019Article
- Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.PloS one · 2019Article
- Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator.Journal of neurophysiology · 2018Article
- Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron.Frontiers in computational neuroscience · 2018Article
- Form and Function of Sleep Spindles across the Lifespan.Neural plasticity · 2016Review
- Inter-expert and intra-expert reliability in sleep spindle scoring.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2015Article
- Global intracellular slow-wave dynamics of the thalamocortical system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The role of T-type calcium channel genes in absence seizures.Frontiers in neurology · 2014Review
- Sleep spindles are generated in the absence of T-type calcium channel-mediated low-threshold burst firing of thalamocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A balance equation determines a switch in neuronal excitability.PLoS computational biology · 2013Article
- Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.PLoS genetics · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The thalamic reticular (RE) nucleus is a major source of inhibition in the thalamus. It plays a crucial role in regulating the excitability of thalamocortical networks and in generating some sleep rhythms. Current-clamp intracellular recordings of RE neurons in cats under barbiturate anesthesia revealed the presence of membrane bistability in approximately 20% of neurons. Bistability consisted of two alternate membrane potentials, separated by approximately 17-20 mV. While non-bistable (common) RE neurons fired rhythmic spike-bursts during spindles, bistable RE neurons fired tonically, with burst modulation, throughout spindle sequences. Bistability was strongly voltage dependent and only expressed under resting conditions (i.e. no current injection). The transition from the silent to the active state was a regenerative event that could be activated by brief depolarization, whereas brief hyperpolarizations could switch the membrane potential from the active to the silent state. These effects outlasted the current pulses. Corticothalamic stimulation could also switch the membrane potential from silent to active states. Addition of QX-314 in the recording micropipette either abolished or disrupted membrane bistability, suggesting I(Na(p)) to be responsible for its generation. Thalamocortical cells presented various patterns of spindling that reflected the membrane bistability in RE neurons. Finally, experimental data and computer simulations predicted a role for RE neurons' membrane bistability in inducing various patterns of spindling in target thalamocortical cells. We conclude that membrane bistability of RE neurons is an intrinsic property, likely generated by I(Na(p)) and modulated by cortical influences, as well as a factor that determines different patterns of spindle rhythms in thalamocortical neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.