ArticleAmerican journal of human genetics2004
Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.Biomolecules · 2022Pooled it
- The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23.Molecular psychiatry · 2006Trial
- Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders.Actas espanolas de psiquiatria · 2025Review
- Review
- Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders.Cellular and molecular neurobiology · 2020Review
- Pharmacoinformatics and molecular docking reveal potential drug candidates against Schizophrenia to target TAAR6.Journal of cellular physiology · 2019Article
- Accelerated pseudogenization of trace amine-associated receptor genes in primates.Genes, brain, and behavior · 2019Article
- 90 years of monoamine oxidase: some progress and some confusion.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders.Frontiers in pharmacology · 2018Article
- Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia.Schizophrenia research · 2017Article
- Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors.Psychopharmacology · 2017Review
- Currently recognized genes for schizophrenia: High-resolution chromosome ideogram representation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Genetic Consideration of Schizotypal Traits: A Review.Frontiers in psychology · 2016Review
- Transcriptome study of differential expression in schizophrenia.Human molecular genetics · 2013Article
- Article
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2011Article
- Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.PloS one · 2011Article
- When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.Science signaling · 2009Review
- International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.Pharmacological reviews · 2009Review
- The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.Schizophrenia research · 2009Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Several linkage studies across multiple population groups provide convergent support for a susceptibility locus for schizophrenia--and, more recently, for bipolar disorder--on chromosome 6q13-q26. We genotyped 192 European-ancestry and African American (AA) pedigrees with schizophrenia from samples that previously showed linkage evidence to 6q13-q26, focusing on the MOXD1-STX7-TRARs gene cluster at 6q23.2, which contains a number of prime candidate genes for schizophrenia. Thirty-one screening single-nucleotide polymorphisms (SNPs) were selected, providing a minimum coverage of at least 1 SNP/20 kb. The association observed with rs4305745 (P=.0014) within the TRAR4 (trace amine receptor 4) gene remained significant after correction for multiple testing. Evidence for association was proportionally stronger in the smaller AA sample. We performed database searches and sequenced genomic DNA in a 30-proband subsample to obtain a high-density map of 23 SNPs spanning 21.6 kb of this gene. Single-SNP analyses and also haplotype analyses revealed that rs4305745 and/or two other polymorphisms in perfect linkage disequilibrium (LD) with rs4305745 appear to be the most likely variants underlying the association of the TRAR4 region with schizophrenia. Comparative genomic analyses further revealed that rs4305745 and/or the associated polymorphisms in complete LD with rs4305745 could potentially affect gene expression. Moreover, RT-PCR studies of various human tissues, including brain, confirm that TRAR4 is preferentially expressed in those brain regions that have been implicated in the pathophysiology of schizophrenia. These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples.
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Registered trials
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