ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Tonotopic gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 96 citations in OpenAlex.
- Avian cochlear nucleus neurons exhibit tonotopic specializations across development.Journal of neurophysiology · 2026Article
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- Central projections of auditory nerve fibers in the western rat snake (Pantherophis obsoletus).The Journal of comparative neurology · 2023Article
- Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.The Journal of comparative neurology · 2022Article
- Expression and Neurotransmitter Association of the Synaptic Calcium Sensor Synaptotagmin in the Avian Auditory Brain Stem.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Slicing the Embryonic Chicken Auditory Brainstem to Evaluate Tonotopic Gradients and Microcircuits.Journal of visualized experiments : JoVE · 2022Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- Tonotopic Specializations in Number, Size, and Reversal Potential of GABAergic Inputs Fine-Tune Temporal Coding at Avian Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spatiotemporal Analysis of Cochlear Nucleus Innervation by Spiral Ganglion Neurons that Serve Distinct Regions of the Cochlea.Neuroscience · 2020Article
- Structural and Functional Refinement of the Axon Initial Segment in Avian Cochlear Nucleus during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Excitatory-Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Tonotopic Differentiation of Coupling between CaiScience · 2019Article
- Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl.Journal of neurophysiology · 2019Article
- Postsynaptic FMRP Regulates SynaptogenesisThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.The Journal of physiology · 2018Article
- Auditory Input Shapes Tonotopic Differentiation of Kv1.1 Expression in Avian Cochlear Nucleus during Late Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Diverse Intrinsic Properties Shape Functional Phenotype of Low-Frequency Neurons in the Auditory Brainstem.Frontiers in cellular neuroscience · 2018Article
- Need for Speed and Precision: Structural and Functional Specialization in the Cochlear Nucleus of the Avian Auditory System.Journal of experimental neuroscience · 2018Review
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleus magnocellularis (NM) is a division of the avian cochlear nucleus that extracts the timing of auditory signals. We compared the membrane excitability and synaptic transmission along the tonotopic axis of NM. Neurons expressed a Kv1.1 potassium channel mRNA and protein predominantly in the high characteristic frequency (CF) region of NM. In contrast, the expression of Kv1.2 mRNA did not change tonotopically. Neurons also showed tonotopic gradients in resting potential, spike threshold, amplitude, and membrane rectification. All neurons were sensitive to 100 nm dendrotoxin, but the effects were most significant in the high CF neurons. The EPSC recorded by minimal stimulation of auditory nerve fibers (ANFs) was 13 times larger in high CF neurons than in low CF neurons. Moreover, EPSCs were generated in an all-or-none manner in the high CF neurons when stimulus intensity was increased, whereas EPSCs were graded in the low CF neurons, indicating multiple axonal inputs. ANF synaptic terminals were visualized by DiI. ANF formed enfolding end-bulbs of Held around the cell body in the high and middle CF region but not in the low CF region. These observations indicate coordinated gradients of neuronal properties both presynaptically and postsynaptically along the tonotopic axis. Such specializations may be suitable for extracting and preserving the timing information of auditory signals over a wide range of acoustic frequencies.
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