ArticleDevelopment (Cambridge, England)2004
Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons.
Article in Development (Cambridge, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 69 citations in OpenAlex.
- Genome-Wide Evolution of Lineage-Specific Chromatin Accessibility Links Regulatory Changes to Cichlid Phenotypic Diversity.Genome biology and evolution · 2026Article
- The roles of cytoplasmic dynein complex in various ocular disorders.Molecular medicine (Cambridge, Mass.) · 2026Review
- Vertically integrated spiking cone photoreceptor arrays for color perception.Nature communications · 2023Article
- Photoreceptor genes in a trechine beetle, Trechiama kuznetsovi, living in the upper hypogean zone.Zoological letters · 2023Article
- Repeated nuclear translocations underlie photoreceptor positioning and lamination of the outer nuclear layer in the mammalian retina.Cell reports · 2021Article
- Evolution of regulatory networks associated with traits under selection in cichlids.Genome biology · 2021Article
- Review
- The genomic basis of cichlid fish adaptation within the deepwater "twilight zone" of Lake Malawi.Evolution letters · 2017Article
- Nuclear envelope: positioning nuclei and organizing synapses.Current opinion in cell biology · 2015Review
- The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.Journal of cell science · 2014Article
- Gathering up meiotic telomeres: a novel function of the microtubule-organizing center.Cellular and molecular life sciences : CMLS · 2014Review
- Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis.Investigative ophthalmology & visual science · 2014Article
- Article
- Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.PloS one · 2014Article
- Construction of a polarized neuron.The Journal of physiology · 2013Review
- Article
- Mitosis in neurons: Roughex and APC/C maintain cell cycle exit to prevent cytokinetic and axonal defects in Drosophila photoreceptor neurons.PLoS genetics · 2012Article
- Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms.Developmental neurobiology · 2011Review
- KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.Human molecular genetics · 2011Article
- Targeting the motor regulator Klar to lipid droplets.BMC cell biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
How a nucleus is positioned within a highly polarized postmitotic animal cell is not well understood. In this work, we demonstrate that the Dynactin complex (a regulator of the microtubule motor protein Dynein) is required to maintain the position of the nucleus within post-mitotic Drosophila melanogaster photoreceptor neurons. We show that multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain, and that inhibiting Dynactin causes the photoreceptor to acquire a bipolar appearance with long leading and trailing processes. We find that while the minus-end directed motor Dynein cooperates with Dynactin in positioning the photoreceptor nucleus, the plus-end directed microtubule motor Kinesin acts antagonistically to Dynactin. These data suggest that the maintenance of photoreceptor nuclear position depends on a balance of plus-end and minus-end directed microtubule motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.