ArticleThe Biochemical journal2005
Proteoglycans and catabolic products of proteoglycans present in ligament.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Anterior cruciate ligament overuse increases collagen fibril compliance: collagen unraveling and elevated glycosaminoglycan activity in a murine model.Acta biomaterialia · 2026Article
- Understanding Anterior Cruciate Ligament Adaptation: Structural, Mechanical, and Healing Considerations.Sports medicine (Auckland, N.Z.) · 2026Review
- Mechanisms of Mucoid Degeneration in the Cruciate Ligament: Role of Denatured Aggrecan Accumulation and Tissue Dysfunction.Orthopedic research and reviews · 2026Review
- Adaptation of Fibril-Reinforced Poroviscoelastic Properties in Rabbit Collateral Ligaments 8 Weeks After Anterior Cruciate Ligament Transection.Annals of biomedical engineering · 2023Article
- Proteoglycans play a role in the viscoelastic behaviour of the canine cranial cruciate ligament.Frontiers in bioengineering and biotechnology · 2022Article
- From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues.Biomolecules · 2020Review
- Extracellular matrix protein production in human adipose-derived mesenchymal stem cells on three-dimensional polycaprolactone (PCL) scaffolds responds to GDF5 or FGF2.Gene reports · 2018Article
- Raman spectroscopy of soft musculoskeletal tissues.Applied spectroscopy · 2014Review
- In vitro tenocyte metabolism in aging and oestrogen deficiency.Age (Dordrecht, Netherlands) · 2013Article
- A comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discs.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2012Article
- Effect of sulfated glycosaminoglycan digestion on the transverse permeability of medial collateral ligament.Journal of biomechanics · 2010Article
- Regeneration of bone- and tendon/ligament-like tissues induced by gene transfer of bone morphogenetic protein-12 in a rat bone defect.Journal of tissue engineering · 2010Article
- Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.Histochemistry and cell biology · 2009Article
- Immunohistochemical and biochemical assay of versican in human sound predentine/dentine matrix.European journal of histochemistry : EJH · 2009Review
- Transversely isotropic distribution of sulfated glycosaminoglycans in human medial collateral ligament: a quantitative analysis.Journal of structural biology · 2009Article
- Contribution of glycosaminoglycans to viscoelastic tensile behavior of human ligament.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Spatial distribution and orientation of dermatan sulfate in human medial collateral ligament.Journal of structural biology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to characterize the proteoglycans and catabolic products of proteoglycans present in the tensile region of ligament and explant cultures of this tissue, and to compare these with those observed in the tensile region of tendon. Approx. 90% of the total proteoglycans in fresh ligament was decorin, as estimated by N-terminal amino acid sequence analysis. Other species that were detected were biglycan and the large proteoglycans versican (splice variants V(0) and/or V1 and/or V2) and aggrecan. Approx. 23% of decorin detected in the matrix was degraded. Intact decorin and decorin fragments similar to those observed in the matrix that retained the N-terminus were also observed in the medium of ligament cultures. Intact biglycan core protein was detected in the matrix and medium of ligament cultures, and two fragments originating from the N-terminal region of biglycan were observed in the matrix of cultured ligament. Versican and versican fragments that retained the N-terminus of versican core protein were detected in fresh matrix and medium of tendon cultures. Approx. 42% of versican present in the fresh ligament was degraded. Aggrecan catabolites appearing in the culture medium were derived from aggrecanase cleavage of the core protein. An intact link protein and a degradation product from the N-terminal region of type XII collagen were also detected in the medium of the ligament explant.
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