ArticleProceedings of the National Academy of Sciences of the United States of America2004
Meager genetic variability of the human malaria agent Plasmodium vivax.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Origin of the human malaria parasite Plasmodium vivax.Trends in parasitology · 2024Review
- Anopheles (Kerteszia) cruzii infected by Plasmodium in the Atlantic Forest indicates that the malaria transmission cycle is maintained even after howler monkeys' population decline.Parasitology research · 2022Article
- Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas.Malaria journal · 2022Review
- The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching.BMC biology · 2021Article
- Population genomic evidence ofScience advances · 2021Article
- Genetic characterization of Plasmodium vivax isolates from Pakistan using circumsporozoite protein (pvcsp) and merozoite surface protein-1 (pvmsp-1) genes as genetic markers.Malaria journal · 2021Article
- Atlantic Forest Malaria: A Review of More than 20 Years of Epidemiological Investigation.Microorganisms · 2021Review
- Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain.Molecular biology and evolution · 2020Article
- Exploration of genetic diversity of Plasmodium vivax circumsporozoite protein (Pvcsp) and Plasmodium vivax sexual stage antigen (Pvs25) among North Indian isolates.Malaria journal · 2019Article
- Origin of the New World Plasmodium vivax: Facts and New Approaches.International microbiology : the official journal of the Spanish Society for Microbiology · 2019Article
- Assessment of asymptomatic Plasmodium spp. infection by detection of parasite DNA in residents of an extra-Amazonian region of Brazil.Malaria journal · 2018Article
- Human migration and the spread of malaria parasites to the New World.Scientific reports · 2018Article
- Article
- Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Genotyping Plasmodium vivax isolates from the 2011 outbreak in Greece.Malaria journal · 2013Article
- Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon.The American journal of tropical medicine and hygiene · 2013Article
- Higher microsatellite diversity in Plasmodium vivax than in sympatric Plasmodium falciparum populations in Pursat, Western Cambodia.Experimental parasitology · 2013Article
- Plasmodium vivax populations revisited: mitochondrial genomes of temperate strains in Asia suggest ancient population expansion.BMC evolutionary biology · 2012Article
- Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination.Malaria journal · 2012Review
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Abstract
Malaria is a major human parasitic disease caused by four species of Plasmodium protozoa. Plasmodium vivax, the most widespread, affects millions of people across Africa, Asia, the Middle East, and Central and South America. We have studied the genetic variability of 13 microsatellite loci in 108 samples from 8 localities in Asia, Africa, South America, and New Guinea. Only one locus is polymorphic; nine are completely monomorphic, and the remaining three are monomorphic in all but one or two populations, which have a rare second allele. In contrast, Plasmodium falciparum displays extensive microsatellite polymorphism within and among populations. We further have analyzed, in 96 samples from the same 8 localities, 8 tandem repeats (TRs) located on a 100-kb contiguous chromosome segment described as highly polymorphic. Each locus exhibits 2-10 alleles in the whole sample but little intrapopulation polymorphism (1-5 alleles with a prevailing allele in most cases). Eight microsatellite loci monomorphic in P. vivax are polymorphic in three of five Plasmodium species related to P. vivax (two to seven individuals sampled). Plasmodium simium, a parasite of New World monkeys, is genetically indistinguishable from P. vivax. At 13 microsatellite loci and at 7 of the 8 TRs, both species share the same (or most common) allele. Scarce microsatellite polymorphism may reflect selective sweeps or population bottlenecks in recent evolutionary history of P. vivax; the differential variability of the TRs may reflect selective processes acting on particular regions of the genome. We infer that the world expansion of P. vivax as a human parasite occurred recently, perhaps <10,000 years ago.
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