ArticleProceedings of the National Academy of Sciences of the United States of America2004
Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering.Frontiers in immunology · 2021Pooled it
- An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- CD4 and LAG-3 from sharks to humans: related molecules with motifs for opposing functions.Frontiers in immunology · 2023Article
- IL-2-mTORC1 signaling coordinates the STAT1/T-bet axis to ensure Th1 cell differentiation and anti-bacterial immune response in fish.PLoS pathogens · 2022Article
- Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes.Marine life science & technology · 2022Review
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system.Immunogenetics · 2021Review
- A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response.Trends in immunology · 2020Review
- Activated Erk Is an Early Retrograde Signal After Spinal Cord Injury in the Lamprey.Frontiers in neuroscience · 2020Article
- Diversity of Immunoglobulin (Ig) Isotypes and the Role of Activation-Induced Cytidine Deaminase (AID) in Fish.Molecular biotechnology · 2018Review
- An inhibitory receptor of VLRB in the agnathan lamprey.Scientific reports · 2016Article
- Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems.Immunogenetics · 2016Review
- Novel Teleost CD4-Bearing Cell Populations Provide Insights into the Evolutionary Origins and Primordial Roles of CD4+ Lymphocytes and CD4+ Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Characterization of Lamprey IL-17 Family Members and Their Receptors.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Evolution of two prototypic T cell lineages.Cellular immunology · 2015Article
- Evolution of B cell immunity.Annual review of animal biosciences · 2013Review
- The research of W.E. Mayer (1953-2012): a spectrum of immune systems.Immunogenetics · 2012Review
- Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen.Infectious disorders drug targets · 2012Review
- Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates.Current genomics · 2012Article
- VLR-based adaptive immunity.Annual review of immunology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
All jawed vertebrates have highly diverse lymphocyte receptors, which allow discrimination between self and nonself antigens as well as the recognition of potential pathogens. Key elements of the anticipatory recombinatorial immune system in jawed vertebrates are the TCR, Ig, and MHC genes, but their ancestral genes have not been found in more basal vertebrates. In this study, we extended our analysis of the transcriptome of lymphocyte-like cells in the lamprey to identify the TCR-like and CD4-like genes. The structural features of these genes and their preferential expression in lymphocytes make them attractive candidates for ancestral TCR and CD4 genes. The TCR-like gene contains both V (variable) and J (joining) sequences in its first exon and exists as a single-copy gene that is invariant. Thus, the TCR-like gene cannot account for the receptor diversity that is required for the immune responses reported for lamprey, but it could have been easily modified to serve as an evolutionary precursor of modern TCR and Ig genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.