ArticleNucleic acids research2004
Thioredoxin can influence gene expression by affecting gyrase activity.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Thioredoxin Modulates Cell Surface Hydrophobicity inFrontiers in microbiology · 2019Article
- Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics inFrontiers in microbiology · 2019Article
- RNase E cleavage shapes the transcriptome ofLife science alliance · 2018Article
- Multiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasis.Communications biology · 2018Article
- Article
- Regulation of gene expression by PrrA in Rhodobacter sphaeroides 2.4.1: role of polyamines and DNA topology.Journal of bacteriology · 2009Article
- YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase.Nucleic acids research · 2008Article
- Role of the global transcriptional regulator PrrA in Rhodobacter sphaeroides 2.4.1: combined transcriptome and proteome analysis.Journal of bacteriology · 2008Article
- Physiological and expression analyses of Agrobacterium tumefaciens trxA, encoding thioredoxin.Journal of bacteriology · 2007Article
- Expression of the trxC gene of Rhodobacter capsulatus: response to cellular redox status is mediated by the transcriptional regulator OxyR.Journal of bacteriology · 2006Article
- Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes.Die Naturwissenschaften · 2006Review
- Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase by affecting its DNA-binding.Nucleic acids research · 2006Article
- pTAC2, -6, and -12 are components of the transcriptionally active plastid chromosome that are required for plastid gene expression.The Plant cell · 2006Article
- RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The expression of many genes of facultatively photosynthetic bacteria of the genus Rhodobacter is controlled by the oxygen tension. Among these are the genes of the puf and puc operons, which encode proteins of the photosynthetic apparatus. Previous results revealed that thioredoxins are involved in the regulated expression of these operons, but it remained unsolved as to the mechanisms by which thioredoxins affect puf and puc expression. Here we show that reduced TrxA of Rhodobacter capsulatus and Rhodobacter sphaeroides and oxidized TrxC of R.capsulatus interact with DNA gyrase and alter its DNA supercoiling activity. While TrxA enhances supercoiling, TrxC exerts a negative effect on this activity. Furthermore, inhibition of gyrase activity strongly reduces puf and puc expression. Our results reveal a new signaling pathway by which oxygen can affect the expression of bacterial genes.
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