ArticleAntimicrobial agents and chemotherapy2004
The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 108 citations in OpenAlex.
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- Comparative genomics analysis of the multidrug-resistantFrontiers in cellular and infection microbiology · 2022Article
- A noncanonical chaperone interacts with drug efflux pumps during their assembly into bacterial outer membranes.PLoS biology · 2022Article
- Persister control by leveraging dormancy associated reduction of antibiotic efflux.PLoS pathogens · 2021Article
- Identified Seaweed Compound Diphenylmethane Serves as an Efflux Pump Inhibitor in Drug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
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- The Role of Proteomics in Bacterial Response to Antibiotics.Pharmaceuticals (Basel, Switzerland) · 2020Review
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- Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.European journal of medicinal chemistry · 2019Article
- Brown and Red Seaweeds Serve as Potential Efflux Pump Inhibitors for Drug-ResistantEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 (Antimicrobial agents and chemotherapy · 2018Article
- Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance.Frontiers in microbiology · 2018Review
- Natural Products as Platforms To Overcome Antibiotic Resistance.Chemical reviews · 2017Review
- Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741.Antimicrobial agents and chemotherapy · 2017Article
- Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.Journal of medicinal chemistry · 2017Article
- Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli.ACS infectious diseases · 2016Article
- Article
- Impact on Bacterial Resistance of Therapeutically Nonequivalent Generics: The Case of Piperacillin-Tazobactam.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.
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