Evidence map›Paper›PMID 15328138›Full record

ArticleAntimicrobial agents and chemotherapy2004

Activities of dicationic compounds against Trichomonas vaginalis.

Andrea L Crowell, Chad E Stephens, Arvind Kumar, David W Boykin, W Evan Secor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Synthesis and Biophysical and Biological Studies ofJournal of medicinal chemistry · 2023
    Article
  2. Article
  3. Trichomonas vaginalis: treatment questions and challenges.Expert review of anti-infective therapy · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea L CrowellDivision of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Services, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724, USA.
Chad E Stephens
Arvind Kumar
David W Boykin
W Evan Secor

Funding

FOCUSED PARALLEL SYNTHESIS OF DICATION ANTIFUNGAL AGENTSR01AI046365 · NIAID · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI TIDWELL, RICHARD R · 2001 to 2003
$1.5M
NIAID NIH HHS R01 AI046365NIAID NIH HHS R01AI46365
6 · The paper itself

Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 microM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

Indexed as

AerobiosisAnaerobiosisAnimalsAntitrichomonal AgentsCationsDNA, ProtozoanDrug Resistance, FungalMagnetic Resonance SpectroscopyMetronidazoleNitroimidazolesTrichomonas vaginalisAntitrichomonal AgentsCationsDNA, ProtozoanMetronidazoleNitroimidazoles

Identifiers

PMID15328138
PMCPMC514753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.