ArticleAntimicrobial agents and chemotherapy2004
Terbinafine resistance mediated by salicylate 1-monooxygenase in Aspergillus nidulans.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Global Emergence ofInfection and drug resistance · 2026Review
- Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2025Review
- Phenanthrene degradation by a flavoprotein monooxygenase fromApplied and environmental microbiology · 2025Article
- Emerging Antifungal Resistance in Fungal Pathogens.Current clinical microbiology reports · 2024Review
- Allylamines, Benzylamines, and Fungal Cell Permeability: A Review of Mechanistic Effects and Usefulness against Fungal Pathogens.Membranes · 2022Review
- Review
- Genetic Analyses of Amphotericin B Susceptibility inJournal of fungi (Basel, Switzerland) · 2021Article
- Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase.Plant physiology · 2021Article
- Discovery and Functional Analysis of a Salicylic Acid Hydroxylase from Aspergillus niger.Applied and environmental microbiology · 2021Article
- Comparative Genomic Analysis ofJournal of fungi (Basel, Switzerland) · 2020Article
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Complementary Proteomics, Genomics approaches identifies potential pathogenicity/virulence factors in Tilletia indica induced under the influence of host factor.Scientific reports · 2019Article
- Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine Resistance.Antimicrobial agents and chemotherapy · 2018Article
- Comparative Transcriptome Analysis Reveals the Mechanism Underlying 3,5-Dibromo-4-Hydroxybenzoate Catabolism via a New Oxidative Decarboxylation Pathway.Applied and environmental microbiology · 2018Article
- Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis.Scientific reports · 2018Article
- Characterization of aFrontiers in microbiology · 2018Article
- Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.Frontiers in microbiology · 2018Review
- Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives.Current genomics · 2016Article
- Functional characterization of salicylate hydroxylase from the fungal endophyte Epichloë festucae.Scientific reports · 2015Article
- Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.Organic letters · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance to antifungal agents is a recurring and growing problem among patients with systemic fungal infections. UV-induced Aspergillus nidulans mutants resistant to terbinafine have been identified, and we report here the characterization of one such gene. A sib-selected, 6.6-kb genomic DNA fragment encodes a salicylate 1-monooxygenase (salA), and a fatty acid synthase subunit (fasC) confers terbinafine resistance upon transformation of a sensitive strain. Subfragments carrying salA but not fasC confer terbinafine resistance. salA is present as a single-copy gene on chromosome VI and encodes a protein of 473 amino acids that is homologous to salicylate 1-monooxygenase, a well-characterized naphthalene-degrading enzyme in bacteria. salA transcript accumulation analysis showed terbinafine-dependent induction in the wild type and the UV-induced mutant Terb7, as well as overexpression in a strain containing the salA subgenomic DNA fragment, probably due to the multicopy effect caused by the transformation event. Additional naphthalene degradation enzyme-coding genes are present in fungal genomes, suggesting that resistance could follow degradation of the naphthalene ring contained in terbinafine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.