ArticleAntimicrobial agents and chemotherapy2004
Increased serum resistance in Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- Genomic evolution and dissemination of non-conjugative virulence plasmid of ST65 carbapenem-resistant and hypervirulentFrontiers in cellular and infection microbiology · 2025Article
- Article
- Crippling of Klebsiella pneumoniae virulence by metformin, N-acetylcysteine and secnidazole.BMC microbiology · 2023Article
- Antimicrobial Resistance Pattern, Pathogenicity and Molecular Properties of HypervirulentMicroorganisms · 2023Article
- Healthcare Facilities as Potential Reservoirs of Antimicrobial ResistantPharmaceuticals (Basel, Switzerland) · 2022Article
- Clinical and genomic analysis of hypermucoviscousFrontiers in cellular and infection microbiology · 2022Article
- Effective Photodynamic Therapy with Ir(III) for Virulent Clinical Isolates of Extended-Spectrum Beta-LactamasePharmaceutics · 2021Article
- β-lactam resistance associated with β-lactamase production and porin alteration in clinical isolates of E. coli and K. pneumoniae.PloS one · 2021Article
- Antibiotic Resistance Profile, Outer Membrane Proteins, Virulence Factors and Genome Sequence Analysis Reveal Clinical Isolates ofFrontiers in cellular and infection microbiology · 2020Article
- iTRAQ-Based Proteomics Reveals Potential Anti-Virulence Targets for ESBL-ProducingInfection and drug resistance · 2020Article
- Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients.Scientific reports · 2019Article
- Effects of the Antimicrobial Peptide LL-37 and Innate Effector Mechanisms in Colistin-ResistantFrontiers in microbiology · 2019Article
- Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Article
- Complement Susceptibility in Relation to Genome Sequence of Recent Klebsiella pneumoniae Isolates from Thai Hospitals.mSphere · 2018Article
- HypervirulentGerms · 2018Article
- High Prevalence of Multidrug-ResistantFrontiers in microbiology · 2018Article
- ESBL-plasmid carriage inGut pathogens · 2018Article
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12 authors.
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Abstract
The aim of this study was to determine whether there is an association between serum resistance, O serotypes, and the production of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae. Ninety ESBL-producing and 178 non-ESBL-producing K. pneumoniae isolates gathered in five European countries were O serotyped and tested for sensitivity to the serum's bactericidal effect. The frequency of serum-resistant isolates was higher among ESBL-producing strains (30%; 27/90 isolates) than among non-ESBL-producing strains (17.9%; 32/178 isolates) (P = 0.037; odds ratio [OR] = 1.96; 95% confidence interval [95% CI] = 1.08 to 3.53). Although O1 was the most common O serotype in both Klebsiella groups, its frequency among ESBL-producing strains was significantly higher (59%; 53/90 isolates) than among non-ESBL producers (36%; 64/178 isolates) (P = 0.0006; OR = 2.5; 95% CI = 1.52 to 4.29). Furthermore, the prevalence of the O1 serotype was higher among serum-resistant strains of both ESBL-producing (74%; 20/27isolates) and non-ESBL producers (75%; 24/32 isolates) than among serum-sensitive ESBL producers (52.4%; 33/63 isolates) and non-ESBL producers (27.4%; 40/146 isolates). Serum resistance among ESBL-producing strains (36%; 17/47 isolates) versus non-ESBL-producing strains (16%; 27/166 isolates) was also significantly higher after the exclusion of clonal strains (P = 0.0056; OR = 2.9; 95% CI = 1.41 to 6.01). Sixteen ESBL types were detected, among which the frequency of serum resistance was significantly lower among the SHV-producing strains (9/48 isolates) than among the TEM producers (16/35 isolates) (P = 0.016; OR = 3.65; CI = 1.3 to 9.7). Curing ESBL-coding plasmids did not influence the serum resistance of the bacteria; all six plasmid-cured derivatives maintained serum resistance. The present findings suggest that ESBL-producing strains have a greater pathogenic potential than non-ESBL-producing strains, but the linkage between O serotypes, serum resistance, and ESBL production remains unclear at this stage.
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