ArticleAntimicrobial agents and chemotherapy2004
The mef(A) gene predominates among seven macrolide resistance genes identified in gram-negative strains representing 13 genera, isolated from healthy Portuguese children.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- Impact of Macrolide Resistance on Azithromycin for Prevention of Rehospitalization or Death Among Children Discharged From Hospitals in Western Kenya.The Journal of infectious diseases · 2025Trial
- Global trends and molecular epidemiology of Azithromycin-resistantOne health (Amsterdam, Netherlands) · 2026Article
- β-Lactamase and Macrolide Resistance Gene Carriage inOpen forum infectious diseases · 2024Article
- Multidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella.Scientific reports · 2024Article
- Microbiological Quality and Antimicrobial Resistance of Commercial Probiotic Products for Food-Producing Animals.Antibiotics (Basel, Switzerland) · 2024Article
- Increasing trend of antibiotic resistance in Shigella in Bangladesh: a plasmid-mediated transfer of mphA macrolide resistance gene.Research square · 2023Article
- Antimicrobial Resistance and Mechanisms of Azithromycin Resistance in Nontyphoidal Salmonella Isolates in Taiwan, 2017 to 2018.Microbiology spectrum · 2023Article
- Identification and genetic characterization of two conjugative plasmids that confer azithromycin resistance inEmerging microbes & infections · 2022Article
- Multiple and High-Risk Clones of Extended-Spectrum Cephalosporin-Resistant andAntibiotics (Basel, Switzerland) · 2021Article
- Virulence Characteristics and Antibiotic Resistance Profiles of Shiga Toxin-ProducingAntibiotics (Basel, Switzerland) · 2020Article
- Azithromycin resistance levels and mechanisms in Escherichia coli.Scientific reports · 2019Article
- Evaluation of Shigella Species Azithromycin CLSI Epidemiological Cutoff Values and Macrolide Resistance Genes.Journal of clinical microbiology · 2019Article
- Detection and expression analysis ofJournal of oral microbiology · 2019Article
- Article
- High Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Among Clinical Isolates From Cats and Dogs Admitted to a Veterinary Hospital in Switzerland.Frontiers in veterinary science · 2018Article
- Mechanisms of Bacterial Resistance to Antimicrobial Agents.Microbiology spectrum · 2018Article
- The macrolide antibiotic renaissance.British journal of pharmacology · 2017Review
- A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015.Antimicrobial agents and chemotherapy · 2017Article
- Clonal Diversity, Virulence Potential and Antimicrobial Resistance ofFrontiers in microbiology · 2017Article
- Resistance to Macrolide Antibiotics in Public Health Pathogens.Cold Spring Harbor perspectives in medicine · 2016Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Of the 176 randomly selected, commensal, gram-negative bacteria isolated from healthy children with low exposure to antibiotics, 138 (78%) carried one or more of the seven macrolide resistance genes tested in this study. These isolates included 79 (91%) isolates from the oral cavity and 59 (66%) isolates from urine samples. The mef(A) gene, coding for an efflux protein, was found in 73 isolates (41%) and was the most frequently carried gene. The mef(A) gene could be transferred from the donors into a gram-positive E. faecalis recipient and a gram-negative Escherichia coli recipient. The erm(B) gene transferred and was maintained in the E. coli transconjugants but was found in 0 to 100% of the E. faecalis transconjugants tested, while the other five genes could be transferred only into the E. coli recipient. The individual macrolide resistance genes were identified in 3 to 12 new genera. Eight (10%) of the oral isolates and 30 (34%) of the urine isolates for which the MICs were 2 to >500 microg of erythromycin per ml did not hybridize with any of the seven genes and may carry novel macrolide resistance genes.
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