ArticleAntimicrobial agents and chemotherapy2004
Impact of alpha interferon and ribavirin on the function of maturing dendritic cells.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.Journal of immunology research · 2020Article
- Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans.Hepatology (Baltimore, Md.) · 2016Article
- Low-dose ribavirin treatments attenuate neuroinflammatory activation of BV-2 Cells by interfering with inducible nitric oxide synthase.Analytical cellular pathology (Amsterdam) · 2015Article
- Role of A20 in interferon-α-mediated functional restoration of myeloid dendritic cells in patients with chronic hepatitis C.Immunology · 2014Article
- Innate immune cell networking in hepatitis C virus infection.Journal of leukocyte biology · 2014Review
- Review
- Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.The Journal of infectious diseases · 2014Article
- The emergence of obsessive compulsive and compulsive buying symptomatology after acute stress and short-term use of ribavirin: case reports.Therapeutic advances in psychopharmacology · 2013Article
- Inhibitory effect of a nucleotide analog on infectious salmon anemia virus infection.Journal of virology · 2011Article
- Hepatitis C virus modulates human monocyte-derived dendritic cells.Journal of viral hepatitis · 2010Article
- Interleukin 27 and viral hepatitis: smarter than the average cytokine.Hepatology (Baltimore, Md.) · 2009Article
- Hepatitis C virus lymphotropism and peculiar immunological phenotype: effects on natural history and antiviral therapy.World journal of gastroenterology · 2009Article
- Hepatitis C and innate immunity: recent advances.Clinics in liver disease · 2008Article
- Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers.Journal of immune based therapies and vaccines · 2008Article
- Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus.Journal of viral hepatitis · 2008Article
- Do DCs influence the antiviral effect of interferon/ribavirin by changing their profile during the therapy?Journal of gastroenterology · 2006Article
- Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression.Current immunology reviews · 2005Article
- Development of antiviral therapy for severe acute respiratory syndrome.Antiviral research · 2005Review
- Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells.Arthritis research & therapy · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Alpha interferon and ribavirin are required in combination to achieve a sustained virological response in the treatment of hepatitis C virus (HCV) infection. Alpha interferon has direct antiviral activity and also enhances HCV-specific T-cell responses. Ribavirin has little direct activity against HCV but reduces hepatic inflammation. It is therefore likely that these drugs in combination have hitherto unidentified immunological effects. In the present study we investigated the effects of alpha interferon and ribavirin on dendritic cell (DC) maturation and cytokine production induced by double-stranded RNA in vitro. Alpha interferon alone enhanced the expression of HLA class I, HLA class II, and CD86 on immature DCs but did not stimulate full DC maturation, which requires the expression of CD83. Alpha interferon enhanced the production of interleukin 12 p70 [IL-12(p70)] and tumor necrosis factor alpha (TNF-alpha) but had no effect on IL-10 production. In contrast, ribavirin at physiological doses had no effect on DC maturation but markedly suppressed the production of TNF-alpha, IL-10, and IL-12(p70). The suppression of cytokines by ribavirin cannot be explained by the induction of DC apoptosis or cell death. Quantitative PCR confirmed that cytokine suppression occurs at the level of mRNA. The suppression of IL-12(p70) and TNF-alpha in maturing DCs may explain the reduction in hepatic inflammation observed during ribavirin monotherapy. Combination alpha interferon-ribavirin therapy may alter the cytokine profile of maturing DCs overall by suppressing IL-10 production but maintaining IL-12(p70) and TNF-alpha production, a pattern that would favor viral elimination through downstream effects on T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.