ArticleAntimicrobial agents and chemotherapy2004
Genome-wide transcriptional profiling of the Escherichia coli response to a proline-rich antimicrobial peptide.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Leveraging antibiotic hormesis for cryptic natural product discovery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- D-amino acid substitution and cyclization enhance the stability and antimicrobial activity of arginine-rich peptides.Microbiology (Reading, England) · 2026Article
- A plant-derived antimicrobial peptide with multiple mechanisms of action exhibiting antibacterial and antibiofilm activities comparable to or superior to polymyxin B.Current research in microbial sciences · 2026Article
- Efflux pump inhibitor chlorpromazine effectively increases the susceptibility ofFuture microbiology · 2024Article
- Interaction of Antimicrobial Peptide Ponericin W1, Thanatin, and Mastatopara-S withFoods (Basel, Switzerland) · 2021Article
- Proline-Rich Peptides with Improved Antimicrobial Activity against E. coli, K. pneumoniae, and A. baumannii.ChemMedChem · 2019Article
- Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions.Frontiers in microbiology · 2019Review
- Reassessing the Host Defense Peptide Landscape.Frontiers in chemistry · 2019Review
- Antimicrobial peptides: biochemical determinants of activity and biophysical techniques of elucidating their functionality.World journal of microbiology & biotechnology · 2018Review
- Microbiological effects of sublethal levels of antibiotics.Nature reviews. Microbiology · 2014Review
- Combined systems approaches reveal highly plastic responses to antimicrobial peptide challenge in Escherichia coli.PLoS pathogens · 2014Article
- Induction of the Cpx envelope stress pathway contributes to Escherichia coli tolerance to antimicrobial peptides.Applied and environmental microbiology · 2013Article
- A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides.BMC microbiology · 2010Article
- The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most antimicrobial peptides (AMPs) impair the viability of target bacteria by permeabilizing bacterial membranes. However, the proline-rich AMPs have been shown to kill susceptible organisms without causing significant membrane perturbation and may act by inhibiting the activity of bacterial targets. To gain initial insight into the events that follow interaction of a proline-rich peptide with bacterial cells, we used DNA macroarray technology to monitor transcriptional alterations of Escherichia coli in response to challenge with a subinhibitory concentration of the proline-rich Bac7(1-35). Substantial changes in the expression levels of 70 bacterial genes from various functional categories were detected. Among these, 26 genes showed decreased expression, while 44 genes, including genes that are potentially involved in bacterial resistance to antimicrobials, showed increased expression. The generation of a transcriptional response under the experimental conditions used is consistent with the ability of Bac7(1-35) to interact with bacterial components and affect biological processes in this organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.