ArticleOncogene2004
Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
- The multifaceted role of lactate in cardiovascular health: from metabolism to signaling and epigenetics.Epigenetics · 2025Review
- Micronutrient intake and telomere length: findings from the UK Biobank.European journal of nutrition · 2024Article
- Role of cellular senescence in inflammation and regeneration.Inflammation and regeneration · 2024Review
- Mapping cellular senescence networks in human diabetic foot ulcers.GeroScience · 2024Article
- Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA).Cancer cell international · 2023Review
- HIV and Drug Use: A Tale of Synergy in Pulmonary Vascular Disease Development.Comprehensive Physiology · 2023Article
- Lipopolysaccharides and Cellular Senescence: Involvement in Atherosclerosis.International journal of molecular sciences · 2022Review
- TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis.Experimental & molecular medicine · 2022Article
- Review
- Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions.Mechanisms of ageing and development · 2021Review
- Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics.Frontiers in pharmacology · 2021Review
- Cellular senescence impairs the reversibility of pulmonary arterial hypertension.Science translational medicine · 2020Article
- Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness.International journal of oral science · 2020Article
- Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation.Brain, behavior, and immunity · 2019Article
- Adalimumab-induced acute myeloid leukaemia in a patient with Crohn's disease.BMJ case reports · 2019Article
- Review
- The biological changes of umbilical cord mesenchymal stem cells in inflammatory environment induced by different cytokines.Molecular and cellular biochemistry · 2018Article
- Oncodriver inhibition and CD4Oncotarget · 2018Article
- The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence.Frontiers in neuroscience · 2018Article
- Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, other studies suggest that this cytokine may elicit other cellular responses such as prolonged growth inhibition. In this context, we have investigated whether TNFalpha may induce senescence in hematopoietic cells, which display intrinsic defect in the apoptotic machinery. The present study described that, in the leukemic KG1 cells, TNFalpha induced no apoptosis but a senescence state characterized by prolonged growth arrest, increased beta-galactosidase activity, p21WAF-1 induction, decreased telomerase activity, telomeric disturbances (shortening, losses, fusions), and additional chromosomal aberrations. Telomerase inhibition correlated with reduced levels of hTERT transcripts. GM-CSF prevented TNFalpha effects and allowed leukemic cells to recover growth capacity. Finally, our study shows for the first time that, at least in some hematopoietic cells, TNFalpha may induce senescence with important functional consequences, including sustained growth inhibition and genetic instability, and that this cellular response is efficiently regulated by hematopoietic growth factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.