ArticleProceedings of the National Academy of Sciences of the United States of America2004
Tau induces cooperative Taxol binding to microtubules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Review
- Cellular mechanisms of traumatic brain injury.npj biological physics and mechanics · 2025Review
- Synthesis of Monofluorinated 7-Hydroxycoumarin-3-Carboxamides as Cell-Permeable Fluorescent Molecular Probes.ACS medicinal chemistry letters · 2024Article
- Preference of CAMSAP3 for expanded microtubule lattice contributes to stabilization of the minus end.Life science alliance · 2023Article
- Quantification of Engagement of Microtubules by Small Molecules in Living Cells by Flow Cytometry.ACS bio & med chem Au · 2022Article
- Direct Cell-Cell Communication via Membrane Pores, Gap Junction Channels, and Tunneling Nanotubes: Medical Relevance of Mitochondrial Exchange.International journal of molecular sciences · 2022Review
- [Protective effect of Epothilone D against traumatic optic nerve injury in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Microtentacle Formation in Ovarian Carcinoma.Cancers · 2022Article
- Pacific Blue-Taxoids as Fluorescent Molecular Probes of Microtubules.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Dichotomous role of microtubule associated protein tau as a biomarker of response to and a target for increasing efficacy of taxane treatment in cancers of epithelial origin.Pharmacological research · 2021Review
- Molecular Encapsulation Inside Microtubules Based on Tau-Derived Peptides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.Frontiers in molecular neuroscience · 2017Article
- The Dark Matter of Biology.Biophysical journal · 2016Review
- Genetic screening reveals a link between Wnt signaling and antitubulin drugs.The pharmacogenomics journal · 2016Article
- Microtubule-Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer Chemotherapy.Medicinal research reviews · 2016Review
- Mechanical Effects of Dynamic Binding between Tau Proteins on Microtubules during Axonal Injury.Biophysical journal · 2015Article
- Article
- Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.Brain : a journal of neurology · 2013Review
- Mechanical properties of doubly stabilized microtubule filaments.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taxol and tau are two ligands that stabilize the microtubule (MT) lattice. Taxol is an anti-mitotic drug that binds beta tubulin in the MT interior. Tau is a MT-associated protein that binds both alpha and beta tubulin on the MT exterior. Both Taxol and tau reduce MT dynamics and promote tubulin polymerization. Tau alone also acts to bundle, stiffen, and space MTs. A structural study recently suggested that Taxol and tau may interact by binding to the same site. Using fluorescence recovery after photobleaching, we find that tau induces Taxol to bind MTs cooperatively depending on the tau concentration. We develop a model that correctly fits the data in the absence of tau, yields the equilibrium dissociation constant of approximately 2 microM, and determines the escape rate of Taxol through one pore to be 1.7 x 10(3) (M x s)(-1). Extension of the model yields a measure of Taxol cooperativity with a Hill coefficient of at least 15 when tau is present at a 1:1 molar ratio with tubulin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.