Evidence map›Paper›PMID 15326073›Full record

Trial reportCirculation2004

Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study.

Shinya Okazaki, Takayuki Yokoyama, Katsumi Miyauchi, Kazunori Shimada, Takeshi Kurata, Hitoshi Sato, Hiroyuki Daida

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01200056 (A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound), which is not on this map. Cited by 138 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 13 pooled it
29.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01200056 phase4completedstarted 2007, after this paper: background citation

A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound

Ran2007Enrolled40Registered outcomes2Posted comparisons0ConditionsCoronary Disease, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Ultrasonography, InterventionalArmsAtorvastatin 10mg versus 40mg.
PMID 15519006PMID 15249516PMID 15755765PMID 15007110PMID 12114036PMID 12476646PMID 12964575PMID 14996776PMID 15238460PMID 12176951PMID 15492303PMID 12390948other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 13 syntheses or guidelines pooled it, 549 citations in OpenAlex.

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  4. Effect of atorvastatin on testosterone levels.The Cochrane database of systematic reviews · 2021
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  10. Statins for acute coronary syndrome.The Cochrane database of systematic reviews · 2014 · on this map
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shinya OkazakiDepartment of Cardiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 Japan. shinya@med.juntendo.ac.jp
Takayuki Yokoyama
Katsumi Miyauchi
Kazunori Shimada
Takeshi Kurata
Hitoshi Sato
Hiroyuki Daida
Juntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent clinical trials have demonstrated that aggressive lipid lowering by statins could prevent recurrent events after acute coronary syndrome (ACS). We hypothesized that this efficacy was caused by a significant reduction in plaque volume by aggressive LDL cholesterol (LCL-C) lowering. The present study investigated the effect of early statin treatment on plaque volume of a nonculprit lesion by serial volumetric intravascular ultrasound in patients with ACS. METHODS AND

resultsSeventy patients with ACS were enrolled. All patients underwent emergency coronary angiography and percutaneous coronary intervention (PCI). They were randomized to intensive lipid-lowering therapy (n=35; atorvastatin 20 mg/d) or control (n=35) groups after PCI. Volumetric intravascular ultrasound analyses were performed at baseline and 6-month follow-up for a non-PCI site in 48 patients (atorvastatin, n=24; control, n=24). LDL-C level was significantly decreased by 41.7% in the atorvastatin group compared with the control group, in which LDL-C was increased by 0.7% (P<0.0001). Plaque volume was significantly reduced in the atorvastatin group (13.1+/-12.8% decrease) compared with the control group (8.7+/-14.9% increase; P<0.0001). Percent change in plaque volume showed a significant positive correlation with follow-up LDL-C level (R=0.456, P=0.0011) and percent LDL-C reduction (R=0.612, P<0.0001), even in patients with baseline LDL-C <125 mg/dL.

conclusionsEarly aggressive lipid-lowering therapy by atorvastatin for 6 months significantly reduced the plaque volume in patients with ACS. Percent change in plaque volume showed a significant positive correlation with percent LDL-C reduction, even in patients with low baseline LDL-C.

Indexed as

Acute DiseaseAgedAngioplasty, Balloon, CoronaryAnticoagulantsAspirinAtorvastatinCardiovascular AgentsCholesterol, LDLCilostazolCombined Modality TherapyCoronary AngiographyCoronary DiseaseFemaleFollow-Up StudiesHeparinHeptanoic AcidsAnticoagulantsAspirinAtorvastatinCardiovascular AgentsCholesterol, LDLCilostazolHeparinHeptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation InhibitorsPyrrolesTetrazolesTiclopidine

Identifiers

PMID15326073
OpenAlexW2157857368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.