ArticleNeurotoxicity research2004
Hippocampal glutamate receptors in fear memory consolidation.
Article in Neurotoxicity research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Oxytocin and Vasopressin Blood Levels in People with Post-Traumatic Stress Disorder.Alpha psychiatry · 2023Article
- A behavioral tagging account of kinase contribution to memory formation after spaced aversive training.iScience · 2023Article
- Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.Molecular brain · 2017Article
- The Effects of Inhaled Pimpinella peregrina Essential Oil on Scopolamine-Induced Memory Impairment, Anxiety, and Depression in Laboratory Rats.Molecular neurobiology · 2016Article
- Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity.Brain structure & function · 2016Article
- Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Pharmacotherapy of PTSD: premises, principles, and priorities.Brain research · 2009Review
- Systemic administration of polyaminergic agents modulate fear conditioning in rats.Psychopharmacology · 2007Article
- Neurotoxins and neurotoxicity mechanisms. An overview.Neurotoxicity research · 2006Review
- Gene-environment interplay in affect and dementia: emotional modulation of cognitive expression in personal outcomes.Neurotoxicity research · 2004Article
- Neurotoxins and neurotoxic species implicated in neurodegeneration.Neurotoxicity research · 2004Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is thought that activity-dependent changes in synaptic efficacy driven by biochemical pathways responsive to the action of the excitatory neurotransmitter glutamate are critical components of the mechanisms responsible for memory formation. In particular, the early activation of the NMDA (rNMDA) and AMPA (rAMPA) subtypes of ionotropic glutamate receptors has been demonstrated to be a necessary event for the acquisition of several types of memory. In the rat, consolidation of the long-term memory for a one-trial, step-down inhibitory avoidance task is blocked by antagonists of the rNMDA and rAMPA infused into the CA1 region of the dorsal hippocampus early after training and is associated with a rapid and reversible increase in the total number of [3H]AMPA binding sites. The learning-induced increase in [[3H]AMPA is accompanied by translocation of the GluR1 subunit of the rAMPA to the post-synaptic terminal together with its phosphorylation at Ser831. In addition, learning of the mentioned fear-motivated task induces the activation and rNMDA-dependent translocation of CaMKII to the post-synaptic density. Inhibition of this protein kinase as well as blockade of the rNMDA abolishes both the learning-induced translocation of GluR1 and its phosphorylation. Our data suggest that learning of an avoidance task enhances hippocampal rAMPA signaling through rNMDA and CaMKII-dependent mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.