Trial reportThe Journal of clinical investigation1992
Hormonal regulation of serum Lp (a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma.
Trial report in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 154 citations in OpenAlex.
- Cardiovascular outcomes in patients with locally advanced and metastatic prostate cancer treated with luteinising-hormone-releasing-hormone agonists or transdermal oestrogen: the randomised, phase 2 MRC PATCH trial (PR09).The Lancet. Oncology · 2013Trial
- Effects of tamoxifen on serum lipid and apolipoprotein levels in postmenopausal patients with breast cancer.Breast cancer research and treatment · 1996Trial
- Dyslipidaemias in cancer patients.European heart journal · 2026Review
- Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.European heart journal · 2022Article
- Molecular, Population, and Clinical Aspects of Lipoprotein(a): A Bridge Too Far?Journal of clinical medicine · 2019Review
- Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease.Indian journal of clinical biochemistry : IJCB · 2016Review
- Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome.Clinical endocrinology · 2016Article
- Enigmatic role of lipoprotein(a) in cardiovascular disease.Clinical and translational science · 2010Article
- Lipid profiles of persons with paraplegia and tetraplegia: sex differences.The journal of spinal cord medicine · 2008Article
- Lipoprotein (A): Better assessor of coronary heart disease risk in south Indian population.Indian journal of clinical biochemistry : IJCB · 2004Article
- Lipoprotein (a) in childhood: correlations with family history of cardiovascular disease.Journal of endocrinological investigation · 2003Article
- Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers.The Biochemical journal · 2002Article
- Effects of exercise on lipoprotein(a).Sports medicine (Auckland, N.Z.) · 1999Review
- Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region.The Journal of clinical investigation · 1997Article
- Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia.The Journal of clinical investigation · 1995Article
- Apolipoprotein(a) phenotypes and lipoprotein(a) concentrations in patients with hyperthyroidism.Journal of molecular medicine (Berlin, Germany) · 1995Article
- Lipoprotein(a): new insights into an atherogenic lipoprotein.The Clinical investigator · 1994Review
- Increased concentrations of serum lipoprotein (a) in response to growth hormone treatment.BMJ (Clinical research ed.) · 1993Article
- Ovarian sex steroids and atherosclerosis.The Clinical investigator · 1993Review
- Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production.The Journal of clinical investigation · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum concentrations of lipoprotein (a) [Lp (a)] were determined in two groups of elderly males suffering from prostatic carcinoma, who were randomized to treatment with estrogen (n = 15) or orchidectomy (n = 16). Estrogen was given as oral ethinylestradiol, 150 micrograms daily, combined with intramuscular polyestradiol phosphate, 80 mg/mo. The baseline levels were similar in both groups, but 6 mo after initiation of therapy, serum Lp (a) levels were decreased approximately 50% in the estrogen-treated group (P less than 0.001) in contrast to a 20% increase (P less than 0.01) in the orchidectomized group. Concomitantly, LDL cholesterol decreased by 30% and HDL cholesterol increased by almost 60% in the estrogen-treated patients. There was no relationship between the change in LDL cholesterol and Lp (a) reduction. In conclusion, Lp (a) levels in males were found to drastically decrease upon estrogen treatment and to increase after orchidectomy, suggesting that sex hormones, and particularly estrogens, exert a regulatory role on the serum Lp (a) level in man.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.