ArticleAmerican journal of human genetics2004
Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Genetic data simulators and their applications: an overview.Genetic epidemiology · 2015Article
- Coordinated conditional simulation with SLINK and SUP of many markers linked or associated to a trait in large pedigrees.Human heredity · 2011Article
- Assessment of transmission distortion on chromosome 6p in healthy individuals using tagSNPs.European journal of human genetics : EJHG · 2009Article
- Article
- Haseman-Elston regression in ascertained samples: importance of dependent variable and mean correction factor selection.Human heredity · 2008Article
- Article
- The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium.American journal of human genetics · 2006Article
- SUP: an extension to SLINK to allow a larger number of marker loci to be simulated in pedigrees conditional on trait values.BMC genetics · 2006Article
- A simple nonparametric multipoint procedure to test for linkage through mothers or fathers as well as imprinting effects in the presence of linkage.BMC genetics · 2005Article
- A high-density screen for linkage in multiple sclerosis.American journal of human genetics · 2005Article
- Mathematical assumptions versus biological reality: myths in affected sib pair linkage analysis.American journal of human genetics · 2005Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the effect of transmission-ratio distortion (TRD) on tests of linkage based on allele sharing in affected sib pairs. We developed and implemented a discrete-trait allele-sharing test statistic, Sad, analogous to the Spairs test statistic of Whittemore and Halpern, that evaluates an excess sharing of alleles at autosomal loci in pairs of affected siblings, as well as a lack of sharing in phenotypically discordant relative pairs, where available. Under the null hypothesis of no linkage, nuclear families with at least two affected siblings and one unaffected sibling have a contribution to Sad that is unbiased, with respect to the effects of TRD independent of the disease under study. If more distantly related unaffected individuals are studied, the bias of Sad is generally reduced compared with that of Spairs, but not completely. Moreover, Sad has higher power, in some circumstances, because of the availability of unaffected relatives, who are ignored in affected-only analyses. We discuss situations in which it may be an efficient use of resources to genotype unaffected relatives, which would give insights for promising study designs. The method is applied to a sample of pedigrees ascertained for asthma in a chromosomal region in which TRD has been reported. Results are consistent with the presence of transmission distortion in that region.
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