ArticleEuropean child & adolescent psychiatry2004
Attention-Deficit Hyperactivity Disorder in the post-genomic era.
Article in European child & adolescent psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A meta-analysis of the prevalence of attention deficit hyperactivity disorder in incarcerated populations.Psychological medicine · 2015Pooled it
- Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Pooled it
- Functional MRI in ADHD: a systematic literature review.Expert review of neurotherapeutics · 2007Pooled it
- Trial
- Independent oscillatory patterns determine performance fluctuations in children with attention deficit/hyperactivity disorder.Brain : a journal of neurology · 2011Trial
- Unraveling the Role of miR-200b-3p in Attention-Deficit/Hyperactivity Disorder (ADHD) and Its Therapeutic Potential in Spontaneously Hypertensive Rats (SHR).Biomedicines · 2024Article
- Disordered eating in early childhood: DRD4 and DAT1 gene polymorphisms and quality of mother-child interaction.Eating and weight disorders : EWD · 2022Article
- Prenatal Tobacco Exposure Modulated the Association of Genetic variants with Diagnosed ADHD and its symptom domain in children: A Community Based Case-Control Study.Scientific reports · 2019Article
- Risk factors for the existence of attention deficit hyperactivity disorder symptoms in children with autism spectrum disorders.Neuropsychiatric disease and treatment · 2017Article
- Association between societal costs and treatment response in children and adolescents with ADHD and their parents. A cross-sectional study in the Netherlands.SpringerPlus · 2015Article
- Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development.Developmental science · 2014Article
- The role of sleep problems and circadian clock genes in childhood psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patterns.BMC psychiatry · 2011Article
- The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence.BMC psychiatry · 2011Article
- Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Separation of cognitive impairments in attention-deficit/hyperactivity disorder into 2 familial factors.Archives of general psychiatry · 2010Article
- Twin studies and their implications for molecular genetic studies: endophenotypes integrate quantitative and molecular genetics in ADHD research.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Review
- Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.Behavioral and brain functions : BBF · 2010Article
- [Methylphenidate. Therapy option for adults with ADHD and comorbid substance use disorder?].Der Nervenarzt · 2010Review
- Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder.European child & adolescent psychiatry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundADHD is a common and complex genetic disorder. Genetic risk factors are expected to be multiple, have small effect sizes when considered individually and to interact with each other and with environmental factors.
objectiveTo describe the difficulties involved in the genetic investigation of such a complex disorder and give a prospective for the future.
methodsReview based on empirical literature and project description.
resultsConsiderable progress has been achieved through the association analysis of candidate gene loci. Linkage scans using affected sibling pairs have identified a number of potential loci that may lead to the identification of novel genes of moderate effect size. Quantitative trait locus (QTL) approaches provide powerful complementary strategies that have the potential to link the categorical disorder to continuously distributed traits associated more closely with underlying genetic liability in the general population. Success in identifying some associated genes has been complemented by functional studies that seek to understand the mode of action of such genes.
conclusionProgress in understanding the mechanisms involved has not been straightforward and many inconsistencies have arisen. In order to take advantage of the potential for progress that stems from the genetic findings it will be important to draw upon a variety of approaches and experimental paradigms. A functional genomic approach to ADHD means that investigation of gene function is carried out at various levels of analysis, not only at the level of molecular and cellular function but also at the level of psychological processes, neuronal networks, environmental interactions and behavioural outcomes.
Indexed as
Identifiers
15322957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.