ReviewJournal of molecular medicine (Berlin, Germany)2004
Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development.
Review in Journal of molecular medicine (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- The role of glutamate receptors in the regulation of the tumor microenvironment.Frontiers in immunology · 2023Pooled it
- Accelerated cancer aggressiveness by viral oncomodulation: New targets and newer natural treatments for cancer control and treatment.Surgical neurology international · 2019Review
- Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness.Oncotarget · 2018Article
- Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas.Oncotarget · 2017Review
- Metabotropic glutamate receptors in cancer.Neuropharmacology · 2017Review
- Sigma receptors [σRs]: biology in normal and diseased states.Journal of receptor and signal transduction research · 2016Article
- Exosomes: The Link between GPCR Activation and Metastatic Potential?Frontiers in genetics · 2016Review
- Glutamate and its receptors in cancer.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Article
- Article
- Role of the nervous system in cancer metastasis.Oncology letters · 2013Article
- GCPII imaging and cancer.Current medicinal chemistry · 2012Review
- Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma.BMC cancer · 2011Article
- Expression of glutamate receptor subunits in human cancers.Histochemistry and cell biology · 2009Article
- Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor.Neuropharmacology · 2008Article
- G-protein-coupled receptors and melanoma.Pigment cell & melanoma research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Melanoma is the aberrant proliferation of melanocytes, the cells in the skin responsible for pigment production. In the United States the current lifetime risk of melanoma development is 1 in 57 in males and 1 in 81 in females. In its early stages melanoma can be surgically removed with great success; however, advanced stages of melanoma have a high mortality rate due to the lack of responsiveness to currently available therapies. The development of animal models to be used in the studies of melanoma will provide the means for developing improved and targeted treatments for this disease. This review focuses on the recent report of a mouse melanoma model, TG-3, which has implicated the ectopic expression of the metabotropic glutamate receptor 1 (Grm1), a G protein coupled receptor (GPCR), in melanomagenesis and metastasis. The involvement of other GPCRs in cellular transformation, particularly GPCRs in melanoma biology, and signaling of Grm1 are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.