ArticleInfection and immunity2004
The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Arrest of nuclear division in Plasmodium through blockage of erythrocyte surface exposed ribosomal protein P2.PLoS pathogens · 2012Trial
- HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Immunogenic Evaluation of Ribosomal P-Protein Antigen P0, P1, and P2 and Pentameric Protein Complex P0-(P1-P2)Journal of immunology research · 2019Article
- Strain-transcending neutralization of malaria parasite by antibodies against Plasmodium falciparum enolase.Malaria journal · 2018Article
- Vaccination with Leishmania infantum acidic ribosomal P0 but not with nucleosomal histones proteins controls Leishmania infantum infection in hamsters.PLoS neglected tropical diseases · 2015Article
- Metabolic perturbations of kidney and spleen in murine cerebral malaria: (1)H NMR-based metabolomic study.PloS one · 2013Article
- Erythrocytic stage-dependent regulation of oligomerization of Plasmodium ribosomal protein P2.The Journal of biological chemistry · 2012Article
- Plasmodium riboprotein PfP0 induces a deviant humoral immune response in Balb/c mice.Journal of biomedicine & biotechnology · 2012Article
- Article
- Multivariate modelling with (1)H NMR of pleural effusion in murine cerebral malaria.Malaria journal · 2011Article
- Cloning and characterization of the acidic ribosomal protein P2 of Cryptosporidium parvum, a new 17-kilodalton antigen.Clinical and vaccine immunology : CVI · 2010Article
- Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression.Malaria journal · 2010Article
- Fine mapping of Plasmodium falciparum ribosomal phosphoprotein PfP0 revealed sequences with highly specific binding activity to human red blood cells.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Can prenatal malaria exposure produce an immune tolerant phenotype? A prospective birth cohort study in Kenya.PLoS medicine · 2009Article
- A shared antigen among Babesia species: ribosomal phosphoprotein P0 as a universal babesial vaccine candidate.Parasitology research · 2007Article
- Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa.PLoS pathogens · 2007Article
- Cloning and characterization of a ribosomal protein L23a from Haemaphysalis qinghaiensis eggs by immuno screening of a cDNA expression library.Experimental & applied acarology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.