Evidence map›Paper›PMID 15322050›Full record

ArticleInfection and immunity2004

The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.

Cristiane C Frota, K G Papavinasasundaram, Elaine O Davis, M Joseph Colston

Abstract read
In one paragraph

Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Transcriptional Profile ofFrontiers in cellular and infection microbiology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cristiane C FrotaDivision of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
K G Papavinasasundaram
Elaine O Davis
M Joseph Colston

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis.

Indexed as

Gene Expression Regulation, BacterialAnimalsAraC Transcription FactorBacterial ProteinsBone MarrowFemaleHumansLungMacrophagesMiceMice, Inbred BALB CMycobacterium tuberculosisRepressor ProteinsTranscription FactorsTuberculosis, PulmonaryVirulenceAraC Transcription FactorBacterial ProteinsRepressor ProteinsTranscription Factors

Identifiers

PMID15322050
PMCPMC517439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.