ArticleInfection and immunity2004
Dendritic cells induce immunity and long-lasting protection against blood-stage malaria despite an in vitro parasite-induced maturation defect.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Innate immunity to malaria: The good, the bad and the unknown.Frontiers in immunology · 2022Review
- Optimization ofBone marrow research · 2018Article
- Atypical activation of dendritic cells byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses.PloS one · 2013Article
- Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives.Rheumatology international · 2012Review
- Article
- Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.The Journal of infectious diseases · 2011Article
- Dual effect of Plasmodium-infected erythrocytes on dendritic cell maturation.Malaria journal · 2010Article
- Investigation of memory responses following Plasmodium chabaudi AS infection in mice distinct in susceptibility to clinical malaria.Parasitology research · 2009Article
- What really happens to dendritic cells during malaria?Nature reviews. Microbiology · 2008Review
- Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.Infection and immunity · 2007Article
- Plasmodium strain determines dendritic cell function essential for survival from malaria.PLoS pathogens · 2007Article
- The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria.Infection and immunity · 2006Article
- Article
- Penetratin tandemly linked to a CTL peptide induces anti-tumour T-cell responses via a cross-presentation pathway.Immunology · 2006Article
- Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine.Arthritis research & therapy · 2006Article
- Malaria pigment paralyzes dendritic cells.Journal of biology · 2006Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DC) suffer a maturation defect following interaction with erythrocytes infected with malaria parasites and become unable to induce protective malaria liver-stage immunity. Here we show that, by contrast, maturation-arrested DC in vitro are capable of the successful induction of antigen-specific gamma interferon (IFN-gamma) and interleukin 4 (IL-4) T-cell responses, antibody responses, and potent protection against lethal blood-stage malaria challenge in vivo. Similar results were found with DC pulsed with intact parasitized Plasmodium yoelii or Plasmodium chabaudi erythrocytes. Cross-strain protection was also induced. High levels of protection (80 to 100%) against lethal challenge were evident from 10 days after a single immunization and maintained up to 120 days. Interestingly, correlation studies versus blood-stage protection at different time points suggest that the immune effector mechanisms associated with protection could change over time. Antibody-independent, T-cell- and IL-12-associated protection was observed early after immunization, followed by antibody and IL-4-associated, IFN-gamma-independent protection in long-term studies. These results indicate that DC, even when clearly susceptible to parasite-induced maturation defect effects in vitro, can be central to the induction of protection against blood-stage malaria in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.