ArticleInfection and immunity2004
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Different antibody isotypes against tuberculosis: what we know and what we need to know.Frontiers in immunology · 2025Review
- Transposon sequencing reveals metabolic pathways essential for Mycobacterium tuberculosis infection.PLoS pathogens · 2024Article
- Mycobacterial Genetic Technologies for Probing the Host-Pathogen Microenvironment.Infection and immunity · 2023Review
- Howard A. Young's 4 Decades in Science: More Than Just Experiments.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Article
- Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.EMBO reports · 2017Article
- Characterization of blue light irradiation effects on pathogenic and nonpathogenic Escherichia coli.MicrobiologyOpen · 2017Article
- A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.Infection and immunity · 2017Article
- Metabolic Perspectives on Persistence.Microbiology spectrum · 2017Review
- Gene Transfer in Mycobacterium tuberculosis: Shuttle Phasmids to Enlightenment.Microbiology spectrum · 2014Review
- Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity.Infection and immunity · 2013Article
- Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.Infection and immunity · 2011Article
- Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.PloS one · 2010Article
- Article
- Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence.Immunogenetics · 2007Review
- Expression profiling in granulomatous lung disease.Proceedings of the American Thoracic Society · 2007Review
- Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.Nature reviews. Genetics · 2006Review
- Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.Microbes and infection · 2006Article
- Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.Infection and immunity · 2006Article
- Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis.Infection and immunity · 2005Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Tuberculosis (TB) is characterized by lifetime persistence of Mycobacterium tuberculosis. Despite the induction of a vigorous host immune response that curtails disease progression in the majority of cases, the organism is not eliminated. Subsequent immunosuppression can lead to reactivation after a prolonged period of clinical latency. Thus, while it is clear that protective immune mechanisms are engaged during M. tuberculosis infection, it also appears that the pathogen has evolved effective countermechanisms. Genetic studies with animal infection models and with patients have revealed a key role for the cytokine gamma interferon (IFN-gamma) in resistance to TB. IFN-gamma activates a large number of antimicrobial pathways. Three of these IFN-gamma-dependent mechanisms have been implicated in defense against M. tuberculosis: inducible nitric oxide synthase (iNOS), phagosome oxidase (phox), and the phagosome-associated GTPase LRG-47. In order to identify bacterial genes that provide protection against specific host immune pathways, we have developed the strategy of differential signature-tagged transposon mutagenesis. Using this approach we have identified three M. tuberculosis genes that are essential for progressive M. tuberculosis growth and rapid lethality in iNOS-deficient mice but not in IFN-gamma-deficient mice. We propose that these genes are involved in pathways that allow M. tuberculosis to counter IFN-gamma-dependent immune mechanisms other than iNOS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.