ArticleInfection and immunity2004
Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- A Narrative Review on the Multifaceted Roles of Galectins in Host-Pathogen Interactions DuringInternational journal of molecular sciences · 2025Review
- Brassica villosa, a system for studying non-glandular trichomes and genes in the Brassicas.Plant molecular biology · 2014Article
- Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer.BMC gastroenterology · 2013Article
- The impact of Helicobacter pylori infection on the gastric microbiota of the rhesus macaque.PloS one · 2013Article
- Article
- Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori.BMC gastroenterology · 2011Article
- A Method to Detect Differential Gene expression in Cross-Species Hybridization Experiments at Gene and Probe Level.Biomedical informatics insights · 2010Article
- Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates.Gastroenterology · 2009Article
- Inhibition of heat shock protein expression by Helicobacter pylori.Microbial pathogenesis · 2009Article
- Roles of galectins in infection.Nature reviews. Microbiology · 2009Review
- Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner.Gastroenterology · 2008Article
- Macaque models of human infectious disease.ILAR journal · 2008Review
- RNA profiling in host-pathogen interactions.Current opinion in microbiology · 2007Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Infection with Helicobacter pylori is usually asymptomatic but sometimes progresses to peptic ulcer disease or gastric adenocarcinoma. The development of disease involves both host and bacterial factors. In order to better understand host factors in pathogenesis, we studied the gastric transcription profile of H. pylori infection in the rhesus macaque by using DNA microarrays. Significant changes were found in the expression of genes important for innate immunity, chemokines and cytokines, cell growth and differentiation, apoptosis, structural proteins, and signal transduction and transcription factors. This broad transcription profile demonstrated expected up-regulation of cell structural elements and the host inflammatory and immune response, as well as the novel finding of down-regulation of heat shock proteins. These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.