ArticleThe American journal of clinical nutrition2004
Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons.
Article in The American journal of clinical nutrition, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 95 citations in OpenAlex.
- Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial.Clinical rheumatology · 2019Trial
- Combination treatment with antioxidants and creatine alleviates common and variant-specific mitochondrial impairments in Leber's hereditary optic neuropathy patient-derived fibroblasts.Human molecular genetics · 2025Article
- The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats.Toxicology reports · 2025Article
- Assessment of Oxidative Stress and Biometric Data in a Captive Colony of Hamadryas Baboons (Veterinary sciences · 2025Article
- Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.Advances in nutrition (Bethesda, Md.) · 2022Review
- Article
- A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice.Nutrients · 2021Article
- Coenzyme QHeliyon · 2020Article
- An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy.Nutrients · 2020Article
- Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode.Molecular biology reports · 2019Article
- Effect of Coenzyme Q10 Supplementation on Serum of High Sensitivity c-reactive Protein Level in Patients with Cardiovascular Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials.International journal of preventive medicine · 2018Review
- Nonhuman Primates and Translational Research-Cardiovascular Disease.ILAR journal · 2017Review
- Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial.Journal of diabetes and metabolic disorders · 2014Article
- C-reactive protein, lipid-soluble micronutrients, and survival in colorectal cancer patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- The effect of season on inflammatory response in captive baboons.Journal of medical primatology · 2012Article
- Age-associated alteration in innate immune response in captive baboons.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Effects of diet on genetic regulation of lipoprotein metabolism in baboons.Atherosclerosis · 2010Article
- Genetic regulation of endothelial inflammatory responses in baboons.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Arterial endothelial dysfunction in baboons fed a high-cholesterol, high-fat diet.The American journal of clinical nutrition · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundInflammation and oxidative stress are processes that mark early metabolic abnormalities in vascular diseases.
objectivesWe explored the effects of a high-fat, high-cholesterol (HFHC) diet on vascular responses in baboons and the potential response-attenuating effects of vitamin E and coenzyme Q(10) (CoQ(10)) supplementation.
designWe used a longitudinal design by subjecting 21 baboons (Papio hamadryas) to sequential dietary challenges.
resultsAfter being maintained for 3 mo on a baseline diet (low in fat and cholesterol), 21 baboons were challenged with an HFHC diet for 7 wk. The serum C-reactive protein (CRP) concentrations did not change. Subsequent supplementation of the HFHC diet with the antioxidant vitamin E (250, 500, or 1000 IU/kg diet) for 2 wk reduced serum CRP concentrations from 0.91 +/- 0.02 to 0.43 +/- 0.06 mg/dL. Additional supplementation with CoQ(10) (2 g/kg diet) further reduced serum CRP to approximately 30% of baseline (0.28 +/- 0.03 mg/dL; P = 0.036 compared with the HFHC diet). Introduction of the HFHC diet itself significantly decreased serum P-selectin (from 48.8 +/- 7.2 to 32.9 +/- 3.7 ng/dL, P = 0.02) and von Willebrand factor (from 187.0 +/- 10.1 to 161.9 +/- 9.0%, P = 0.02) concentrations. However, neither vitamin E alone nor vitamin E plus CoQ(10) significantly altered the serum concentrations of P-selectin or von Willebrand factor.
conclusionsDietary supplementation with vitamin E alone reduces the baseline inflammatory status that is indicated by the CRP concentration in healthy adult baboons. Cosupplementation with CoQ(10), however, significantly enhances this antiinflammatory effect of vitamin E.
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