ArticleClinical and experimental immunology2004
Cytokine expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - implication for T-cell responses.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 89 citations in OpenAlex.
- Biological factors that place women at risk for HIV: evidence from a large-scale clinical trial in Durban.BMC women's health · 2016Trial
- Chlamydia trachomatis orchestrates multifaceted host cell manipulation for immune evasion.Communications biology · 2026Review
- Multi-omics integration of the vaginal microbiome and inflammatory proteome for non-invasive prediction of infertility: a machine learning approach.Frontiers in cell and developmental biology · 2026Article
- UnveilingiScience · 2025Article
- Implication of the Vaginal Microbiome in Female Infertility and Assisted Conception Outcomes.Genomics, proteomics & bioinformatics · 2025Article
- Viral Vector-BasedVaccines · 2024Article
- The role of infected epithelial cells inFrontiers in cellular and infection microbiology · 2023Review
- Impact of First-Line Antimicrobials onFrontiers in microbiology · 2021Article
- Identifying and managing infectious disease syndemics in patients with HIV.Current opinion in HIV and AIDS · 2020Review
- Inferring Regulatory Networks From Mixed Observational Data Using Directed Acyclic Graphs.Frontiers in genetics · 2020Article
- Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.The Journal of infectious diseases · 2019Article
- Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.The American journal of pathology · 2019Article
- Microbial Composition Predicts Genital Tract Inflammation and Persistent Bacterial Vaginosis in South African Adolescent Females.Infection and immunity · 2018Article
- Article
- Genital inflammation, immune activation and risk of sexual HIV acquisition.Current opinion in HIV and AIDS · 2016Review
- Potential protective effect of a G>A SNP in the 3'UTR of HLA-A for Chlamydia trachomatis symptomatology and severity of infection.Pathogens and disease · 2016Article
- Individual and Population Level Impact of Key HIV Risk Factors on HIV Incidence Rates in Durban, South Africa.PloS one · 2016Article
- Significant roles played by IL-10 in Chlamydia infections.Inflammation · 2014Review
- Signaling via tumor necrosis factor receptor 1 but not Toll-like receptor 2 contributes significantly to hydrosalpinx development following Chlamydia muridarum infection.Infection and immunity · 2014Article
- Differential profiles of immune mediators and in vitro HIV infectivity between endocervical and vaginal secretions from women with Chlamydia trachomatis infection: a pilot study.Journal of reproductive immunology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human genital infection caused by Chlamydia trachomatis is thought to be immunologically mediated, resulting in local recruitment of lymphocyte subsets and inducing the production of cytokines. Little information is available about the role of lymphocyte recruitment and the regulation of cytokine production in the genital tract of C. trachomatis positive infertile women. We have evaluated the recruitment of lymphocyte subsets in the genital tract and production of Th1/Th2 cytokines in cervical secretions and laparoscopic specimens from the fallopian tubes of C. trachomatis positive infertile women (n = 17) and compared them with controls, viz. C. trachomatis negative infertile women (n = 20) using ELISA and flow cytometry. None of these patients were found to be infected either with Candida sps., bacterial vaginosis, Trichomonas vaginalis, Neisseria gonorrhoeae, Mycoplasma hominis or Ureaplasma urealyticum in the cervix. Flow cytometric analysis of cervical secretions in Chlamydia positive women revealed recruitment of both CD4 and CD8 lymphocytes to the genital tract was up-regulated and a variation in the production rates of different cytokines in cervical secretions and fallopian tube was observed. We found that the immune responses in cervical secretions were of Th0 type, since all the analysed cytokines, viz. IFN-gamma, TNF-alpha, IL-10 and IL-12 were up-regulated. As, both CD4 and CD8 cells contribute to the production of IFN-gamma and IL-10, these results suggest that along with CD4 cells, CD8 lymphocytes also may be important for local regulation of Th1/Th2 responses in the genital tract during C. trachomatis infection.
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