ArticleThe Journal of physiology2004
Activity-dependent excitability changes in hippocampal CA3 cell Schaffer axons.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- The Slow Depolarization Following Individual Spikes in Thin, Unmyelinated Axons in Mammalian Cortex.Frontiers in cellular neuroscience · 2019Article
- Resistance to action potential depression of a rat axon terminal in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Furosemide depresses the presynaptic fiber volley and modifies frequency-dependent axonal excitability in rat hippocampus.Journal of neurophysiology · 2017Article
- High-fidelity optical excitation of cortico-cortical projections at physiological frequencies.Journal of neurophysiology · 2016Article
- Typical gray matter axons in mammalian brain fail to conduct action potentials faithfully at fever-like temperatures.Physiological reports · 2016Article
- Activity-dependent differences in function between proximal and distal Schaffer collaterals.Journal of neurophysiology · 2015Article
- Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.Journal of neurophysiology · 2012Article
- Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies.Journal of neural engineering · 2012Article
- Comparing the effects of mineral trioxide aggregate and calcium enriched mixture on neuronal cells using an electrophysiological approach.Iranian endodontic journal · 2012Article
- Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.Progress in neurobiology · 2011Review
- Sound stimulation modulates high-threshold K(+) currents in mouse auditory brainstem neurons.The European journal of neuroscience · 2010Article
- Potassium diffusive coupling in neural networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Chronic network stimulation enhances evoked action potentials.Journal of neural engineering · 2010Article
- High frequency stimulation can block axonal conduction.Experimental neurology · 2009Article
- Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates.Journal of neuroscience methods · 2009Article
- The membrane response of hippocampal CA3b pyramidal neurons near rest: Heterogeneity of passive properties and the contribution of hyperpolarization-activated currents.Neuroscience · 2009Article
- Action potential initiation and propagation: upstream influences on neurotransmission.Neuroscience · 2009Review
- Effective release rates at single rat Schaffer collateral-CA1 synapses during sustained theta-burst activity revealed by optical imaging.The Journal of physiology · 2007Article
- Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The membrane potential changes following action potentials in thin unmyelinated cortical axons with en passant boutons may be important for synaptic release and conduction abilities of such axons. In the lack of intra-axonal recording techniques we have used extracellular excitability testing as an indirect measure of the after-potentials. We recorded from individual CA3 soma in hippocampal slices and activated the axon with a range of stimulus intensities. When conditioning and test stimuli were given to the same site the excitability changes were partly masked by local effects of the stimulating electrode at intervals < 5 ms. Therefore, we elicited the conditioning action potential from one axonal branch and tested the excitability of another branch. We found that a single action potential reduced the axonal excitability for 15 ms followed by an increased excitability for approximately 200 ms at 24 degrees C. Using field recordings of axonal action potentials we show that raising the temperature to 34 degrees C reduced the magnitude and duration of the initial depression. However, the duration of the increased excitability was very similar (time constant 135 +/- 20 ms) at 24 and 34 degrees C, and with 2.0 and 0.5 mM Ca2+ in the bath. At stimulus rates > 1 Hz, a condition that activates a hyperpolarization-activated current (Ih) in these axons, the decay was faster than at lower stimulation rates. This effect was reduced by the Ih blocker ZD7288. These data suggest that the decay time course of the action potential-induced hyperexcitability is determined by the membrane time constant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.