ArticleThe Journal of clinical investigation1992
Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 155 citations in OpenAlex.
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- Single-Dose Treatment with Rapamycin Preserves Post-Ischemic Cardiac Function through Attenuation of Fibrosis and Inflammation in Diabetic Rabbit.International journal of molecular sciences · 2023Article
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- From pediatrics to geriatrics: Mechanisms of heart failure across the life-course.Journal of molecular and cellular cardiology · 2019Review
- Serum Response Factor in Muscle Tissues: From Development to Ageing.European journal of translational myology · 2016Article
- Mechanical Regulation of Cardiac Aging in Model Systems.Circulation research · 2016Review
- Aging and Autophagy in the Heart.Circulation research · 2016Review
- The role of sirtuins in cardiac disease.American journal of physiology. Heart and circulatory physiology · 2015Review
- MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes.BioMed research international · 2015Article
- Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure.Biochimica et biophysica acta · 2015Review
- Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Increase in cardiac myosin heavy-chain (MyHC) alpha protein isoform in hibernating ground squirrels, with echocardiographic visualization of ventricular wall hypertrophy and prolonged contraction.The Journal of experimental biology · 2013Article
- Modulation of sarcoplasmic reticulum Ca(2+) cycling in systolic and diastolic heart failure associated with aging.Heart failure reviews · 2010Article
- Myocardial alterations in senescent mice and effect of exercise training: a strain rate imaging study.Circulation. Cardiovascular imaging · 2008Article
- Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction.Journal of the American College of Cardiology · 2008Article
- Assessment of right ventricular fibrosis in different forms of pulmonary atresia with ventricular septal defect.Experimental and clinical cardiology · 2004Article
- Right ventricular collagen and fibronectin levels in patients with pulmonary atresia and ventricular septal defect.Molecular and cellular biochemistry · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and qualitative (pattern of gene expression) changes. Our previous studies have shown that advancing age in the rat is associated with diminished capacity to develop left ventricular hypertrophy in response to either ascending aortic constriction (AoC). In this study, we examined whether the expression of protooncogenes and contractile protein genes in response to AoC differs between adult (9-mo-old) and old (18-mo-old) rats. RNA was isolated from the left ventricles of AoC animals of both age groups subjected to a similar hemodynamic stress. Immediately after AoC, the levels of the ventricular expression of c-fos and c-jun protooncogenes were markedly lower in the old rats than in the adult animals. 5 d after the operation, the ratio of beta- to alpha-myosin heavy chain mRNAs increased significantly after AoC in both age groups. In contrast, AoC was associated with a marked reduction in the levels of mRNAs encoding sarcoplasmic reticulum Ca(2+)-ATPase (by 69%) and cardiac calsequestrin (by 49%) in the old rats but not in the adults. The mRNAs encoding atrial natriuretic factor and skeletal alpha-actin increased in response to AoC only in the adult rats. There were no significant differences in expression of the cardiac alpha-actin mRNA among the experimental groups. These data suggest that (a) the expression of protooncogenes in response to acute pressure overload is significantly reduced in the aged rats and (b) the pattern of expression of the contractile protein gene in response to AoC in the old rats differs qualitatively as well as quantitatively from that in younger animals. These age-related differences may play a role in the higher frequency of heart failure in the aged during hemodynamic stress.
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