ArticleProceedings of the National Academy of Sciences of the United States of America2004
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells.iScience · 2023Article
- Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.Oncogene · 2017Article
- Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration.Physiological genomics · 2017Article
- Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.Molecular psychiatry · 2014Article
- Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.The Journal of biological chemistry · 2013Article
- Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB.Nature · 2011Article
- Beta-catenin signaling in hepatic development and progenitors: which way does the WNT blow?Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice.Gastroenterology · 2009Article
- Foxo1 integrates insulin signaling with mitochondrial function in the liver.Nature medicine · 2009Article
- Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.Hepatology (Baltimore, Md.) · 2009Article
- Identification of neuronal target genes for CCAAT/enhancer binding proteins.Molecular and cellular neurosciences · 2009Article
- Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Genes & development · 2008Article
- Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat.BMC genomics · 2008Article
- Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growth.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.Nucleic acids research · 2008Article
- CCAAT/enhancer binding protein-beta is a transcriptional regulator of peroxisome-proliferator-activated receptor-gamma coactivator-1alpha in the regenerating liver.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Liver regeneration.Journal of cellular physiology · 2007Review
- Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.Genes & development · 2007Article
- Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
CCAAT enhancer-binding protein beta (C/EBPbeta), a basic-leucine zipper transcription factor, is an important effector of signals in physiologic growth and cancer. The identification of direct C/EBPbeta targets in vivo has been limited by functional compensation by other C/EBP family proteins and the low stringency of the consensus sequence. Here we use the combined power of expression profiling and high-throughput chromatin immunoprecipitation to identify direct and biologically relevant targets of C/EBPbeta. We identified 25 potential C/EBPbeta targets, of which 88% of those tested were confirmed as in vivo C/EBPbeta-binding sites. Six of these genes also displayed differential expression in C/EBPbeta-/- livers. Computational analysis revealed that bona fide C/EBPbeta target genes can be distinguished by the presence of binding motifs for specific additional transcription factors in the vicinity of the C/EBPbeta site. This approach is generally applicable to the discovery of direct, biologically relevant targets of mammalian transcription factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.