ArticleJournal of bacteriology2004
Identification of Lactobacillus plantarum genes that are induced in the gastrointestinal tract of mice.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
What it found
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Who cites it
99 citing papers in PubMed.
- Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2009Trial
- Integrated Genome-Based and In Vivo Safety Evaluation of Lactiplantibacillus plantarum M2, an Isolate Obtained from the Amazonian Fruit Humiria balsamifera.Probiotics and antimicrobial proteins · 2026Article
- Pangenome-based design of strain-specific primers enables precise monitoring of bacteria in human microbiome intervention trials.Scientific reports · 2026Article
- Direct-fed Microbials (DFM) and Poultry Genomics: A Synergistic Approach to Sustainable Antibiotic Free Farming.Probiotics and antimicrobial proteins · 2026Review
- A genomics-based investigation of acetic acid bacteria across a global fermented food metagenomics dataset.iScience · 2025Article
- Biotics and Children's and Adolescents' Health: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions.Frontiers in physiology · 2023Review
- Molecular Responses of Lactobacilli to Plant Phenolic Compounds: A Comparative Review of the Mechanisms Involved.Antioxidants (Basel, Switzerland) · 2021Review
- Identification ofMicroorganisms · 2021Article
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- Microbiota Assessments for the Identification and Confirmation of Slit Defect-Causing Bacteria in Milk and Cheddar Cheese.mSystems · 2021Article
- The Possible Link Between Manufacturing and Probiotic Efficacy; a Molecular Point of View onFrontiers in microbiology · 2021Review
- Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods.Microbial cell factories · 2020Review
- Application of Recombinase-Based In Vivo Expression Technology toMicroorganisms · 2020Article
- Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles.Infection and immunity · 2019Article
- Molecular Switch Controlling Expression of the Mannose-Specific Adhesin, Msa, inApplied and environmental microbiology · 2019Article
- AcrR and Rex Control Mannitol and Sorbitol Utilization through Their Cross-Regulation of Aldehyde-Alcohol Dehydrogenase (AdhE) in Lactobacillus plantarum.Applied and environmental microbiology · 2019Article
- Engineering bacteria for diagnostic and therapeutic applications.Nature reviews. Microbiology · 2018Review
- Enhancing water stress tolerance improves fitness in biological control strains of Lactobacillus plantarum in plant environments.PloS one · 2018Article
- A Review: The Fate of Bacteriocins in the Human Gastro-Intestinal Tract: Do They Cross the Gut-Blood Barrier?Frontiers in microbiology · 2018Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactobacillus plantarum is a flexible and versatile microorganism that inhabits a variety of environmental niches, including the human gastrointestinal (GI) tract. Moreover, this lactic acid bacterium can survive passage through the human or mouse stomach in an active form. To investigate the genetic background of this persistence, resolvase-based in vivo expression technology (R-IVET) was performed in L. plantarum WCFS1 by using the mouse GI tract as a model system. This approach identified 72 L. plantarum genes whose expression was induced during passage through the GI tract as compared to laboratory media. Nine of these genes encode sugar-related functions, including ribose, cellobiose, sucrose, and sorbitol transporter genes. Another nine genes encode functions involved in acquisition and synthesis of amino acids, nucleotides, cofactors, and vitamins, indicating their limited availability in the GI tract. Four genes involved in stress-related functions were identified, reflecting the harsh conditions that L. plantarum encounters in the GI tract. The four extracellular protein encoding genes identified could potentially be involved in interaction with host specific factors. The rest of the genes are part of several functionally unrelated pathways or encode (conserved) hypothetical proteins. Remarkably, a large number of the functions or pathways identified here have previously been identified in pathogens as being important in vivo during infection, strongly suggesting that survival rather than virulence is the explanation for the importance of these genes during host residence.
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