ArticleJournal of neurology2004
The significance of titin antibodies in myasthenia gravis--correlation with thymoma and severity of myasthenia gravis.
Article in Journal of neurology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Efgartigimod as Rescue Therapy for PD-1 Inhibitor-Associated Myasthenia Gravis, Myocarditis, and Myositis (MMM) Syndrome: A 2-Case Report and Literature Review.The American journal of case reports · 2026Review
- Multi-omics profiling reveals intrathymic triggers and novel biomarkers in thymoma-associated myasthenia gravis.Biomarker research · 2026Article
- Review
- Serological diagnosis of myasthenia gravis and its clinical significance.Annals of translational medicine · 2023Review
- A narrative review of identifying the culprit antibody in neuroimmune diseases: concept and clinical significance.Annals of translational medicine · 2023Review
- Anti-titin antibodies are associated with myocarditis in patients with myasthenia gravis.Journal of neurology · 2023Article
- Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis.Biomedicines · 2023Article
- Case Report: Telitacicept in severe myasthenia gravis: a case study with multiple autoantibodies.Frontiers in immunology · 2023Article
- Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis.Frontiers in neurology · 2022Article
- Immunopathology of Autoimmune Myasthenia Gravis: Implications for Improved Testing Algorithms and Treatment Strategies.Frontiers in neurology · 2020Review
- Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics.Frontiers in immunology · 2020Review
- Prognostic Analysis of Thymoma-Associated Myasthenia Gravis (MG) in Chinese Patients and Its Implication of MG Management: Experiences from a Tertiary Hospital.Neuropsychiatric disease and treatment · 2020Article
- Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management.Frontiers in neurology · 2020Review
- Paraneoplastic pemphigus: a clinical, laboratorial, and therapeutic overview.Anais brasileiros de dermatologia · 2019Article
- Stretch your heart-but not too far: The role of titin mutations in dilated cardiomyopathy.The Journal of thoracic and cardiovascular surgery · 2018Review
- Screening for lipoprotein receptor-related protein 4-, agrin-, and titin-antibodies and exploring the autoimmune spectrum in myasthenia gravis.Journal of neurology · 2017Article
- Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens.Immunology and cell biology · 2015Article
- Exosomes in the Thymus: Antigen Transfer and Vesicles.Frontiers in immunology · 2015Review
- Incidence of thymoma in myasthenia gravis: a systematic review.Journal of clinical neurology (Seoul, Korea) · 2012Article
- Three types of striational antibodies in myasthenia gravis.Autoimmune diseases · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myasthenia gravis (MG) is caused by autoantibodies to acetylcholine receptors (AChR). Non-AChR muscle autoantibodies, such as titin antibodies, are present in sera of many MG patients. To study the correlation between titin antibodies and the features of MG, the cDNA segment encoding MGT-30 was amplified and sequenced. The cloned MGT-30 cDNA was expressed in vector pET-30a, and then transfected into E.coli. BL21. We examined titin antibodies in sera of 265 normal subjects, 154 MG patients with different thymic pathology and 48 patients with other neurological diseases. Titin antibodies occurred more frequently in MGT, especially in MG with epithelial predominant-thymoma, and were correlated with the severity of disease. The levels of titin antibodies were reduced 6 months after thymectomy. The specificity of titin antibodies for the detection of thymoma was higher than that of CT examination in MG with thymoma. These results suggest that titin antibodies could be useful in both diagnosis and follow-up of MG patients with thymoma.
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Registered trials
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