ArticleImmunogenetics2004
Genomic organization and evolutionary analysis of Ly49 genes encoding the rodent natural killer cell receptors: rapid evolution by repeated gene duplication.
Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- Gene number determination and genetic polymorphism of the gamma delta T cell co-receptor WC1 genes.BMC genetics · 2012Article
- Evolution of the C-type lectin-like receptor genes of the DECTIN-1 cluster in the NK gene complex.TheScientificWorldJournal · 2012Review
- Genomic organization and classification of the bovine WC1 genes and expression by peripheral blood gamma delta T cells.BMC genomics · 2009Article
- NK gene complex dynamics and selection for NK cell receptors.Seminars in immunology · 2008Review
- Detecting the effects of selection at the population level in six bovine immune genes.BMC genetics · 2008Article
- Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8.Immunogenetics · 2007Article
- Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution.Immunogenetics · 2006Article
- Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Complete elucidation of a minimal class I MHC natural killer cell receptor haplotype.Genes and immunity · 2005Article
- Comparative genomics of natural killer cell receptor gene clusters.PLoS genetics · 2005Article
- Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Origin and evolution of the chicken leukocyte receptor complex.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Concerted and birth-and-death evolution of multigene families.Annual review of genetics · 2005Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ly49 genes regulate the cytotoxic activity of natural killer (NK) cells in rodents and provide important protection against virus-infected or tumor cells. About 15 Ly49 genes have been identified in mice, but only a few genes have been reported to date in rats. Here we studied all Ly49 genes in the entire rat genome sequence and identified 17 putative functional and 16 putative non-functional genes together with their genomic locations in a 1.8-Mb region of chromosome 4. Phylogenetic analysis of these genes indicated that the Ly49 gene family expanded rapidly in recent years, and this expansion was mediated by both tandem and genomic block duplication. The joint phylogenetic analysis of mouse and rat genes suggested that the most recent common ancestor of the two species had at least several Ly49 genes, but that the majority of current duplicate genes were generated after divergence of the two species. In both species Ly49 genes are apparently subject to birth-and-death evolution, but the birth and death rates of Ly49 genes are higher in rats than in mice. The rate of gene expansion in the Ly49 gene family in rats is one of the highest among all mammalian multigene families so far studied. The biochemical function of Ly49 genes is essentially the same as that of KIR genes in primates, but the molecular structures of the two groups of NK cell receptors are very different. A hypothesis was presented to explain the origin of the differential use of Ly49 and KIR genes in rodents and primates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.