ArticleProceedings of the National Academy of Sciences of the United States of America1992
Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 169 citations in OpenAlex.
- Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways.Biomedicines · 2021Review
- Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Frontiers in pharmacology · 2020Article
- Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract ofFrontiers in pharmacology · 2019Article
- Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.Biophysical journal · 2012Article
- Regulation of cardiac excitability by protein kinase C isozymes.Frontiers in bioscience (Scholar edition) · 2012Review
- Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.American journal of physiology. Heart and circulatory physiology · 2011Article
- Elucidating the role of reversible protein phosphorylation in sepsis-induced myocardial dysfunction.Shock (Augusta, Ga.) · 2009Review
- LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.American journal of physiology. Heart and circulatory physiology · 2009Article
- Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta.The Journal of biological chemistry · 2008Article
- Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition.American journal of physiology. Heart and circulatory physiology · 2008Article
- Cytochrome c oxidase subunit IV as a marker of protein kinase Cepsilon function in neonatal cardiac myocytes: implications for cytochrome c oxidase activity.The Biochemical journal · 2004Article
- Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.The Journal of clinical investigation · 2001Article
- G-proteins in growth and apoptosis: lessons from the heart.Oncogene · 2001Review
- Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro.The Biochemical journal · 2000Article
- Inhibition of norepinephrine-induced cardiac hypertrophy in s100beta transgenic mice.The Journal of clinical investigation · 1998Article
- Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.The Journal of clinical investigation · 1997Article
- Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes.The Biochemical journal · 1997Article
- Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.The Journal of clinical investigation · 1995Article
- Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.The Journal of clinical investigation · 1995Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A cultured myocardial cell model was used to examine the role of protein kinase C-dependent pathways in the transcriptional activation of two cardiac muscle genes [myosin light chain 2 (MLC-2) and atrial natriuretic factor (ANF)] during alpha-adrenergic receptor-mediated hypertrophy. Phorbol ester (phorbol 12-myristate 13-acetate) and the alpha-adrenergic agonist phenylephrine both activate protein kinase C (PKC) and induce 4- to 5-fold increases in the expression of MLC-2 and ANF promoter/luciferase reporter genes with little effect on Rous sarcoma virus/luciferase or minimal prolactin promoter/luciferase genes. To further assess the role of PKC in cardiac gene regulation, PKC expression vectors encoding constitutively activated PKC-alpha or PKC-beta, or a catalytically inactive PKC, were transiently cotransfected with the cardiac promoter/luciferase constructs. Cotransfection of either activated PKC-alpha or PKC-beta cDNA induces the expression of MLC-2 and ANF promoter/luciferase genes and of a reporter gene responsive to the transcription factor AP-1. The Rous sarcoma virus/luciferase and minimal prolactin promoter/luciferase genes are not concomitantly induced by cotransfectin with the PKC genes, indicating specificity of the transcriptional effect. The finding that activated PKC increases cardiac gene transcription suggests that activation of this enzyme may be a proximal signal for coregulation of two cardiac genes, MLC-2 and ANF, during the course of myocardial cell hypertrophy.
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