ReviewThe Journal of clinical investigation2004
The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis.
Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 92 citations in OpenAlex.
- Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2007Trial
- Acidosis regulates immune progression in rheumatoid arthritis by promoting the expression of cytokines and co-stimulatory molecules in synovial fibroblasts.Molecular medicine (Cambridge, Mass.) · 2025Article
- Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity.Frontiers in cell and developmental biology · 2022Review
- Combination of COX-2 inhibitor and metformin attenuates rate of admission in patients with rheumatoid arthritis and diabetes in Taiwan.Medicine · 2019Article
- Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review.Arthritis research & therapy · 2018Review
- The Physiological Role of Tumor Necrosis Factor in Human Immunity and Its Potential Implications in Spinal Manipulative Therapy: A Narrative Literature Review.Journal of chiropractic medicine · 2016Article
- Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules.BMB reports · 2016Article
- Gut inflammation and microbiome in spondyloarthritis.Rheumatology international · 2016Review
- Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.The Journal of biological chemistry · 2015Article
- The future of osteoarthritis therapeutics: emerging biological therapy.Current rheumatology reports · 2013Review
- Periarticular bone loss in antigen-induced arthritis.Arthritis and rheumatism · 2013Article
- Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αβ and are elevated in rheumatoid arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Reactive oxygen species delay control of lymphocytic choriomeningitis virus.Cell death and differentiation · 2013Article
- Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.International immunopharmacology · 2012Article
- The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases.The open rheumatology journal · 2012Article
- Protein array diagnostics for guiding therapy in rheumatoid arthritis.Molecular diagnosis & therapy · 2011Review
- Mammary transplantation of stromal cells and carcinoma cells in C57BL/6J mice.Journal of visualized experiments : JoVE · 2011Article
- Characterization of a novel and spontaneous mouse model of inflammatory arthritis.Arthritis research & therapy · 2011Article
- Development of anti-CD20 therapy for multiple sclerosis.Experimental cell research · 2011Review
- Kinetic analysis of synovial signalling and gene expression in animal models of arthritis.Annals of the rheumatic diseases · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of autoimmunity in humans remains poorly defined, and animal models provide a unique opportunity to study potential autoimmune mechanisms. A novel model of autoimmune inflammatory arthritis results from a point mutation in the zeta-associated-protein of 70 kDa (ZAP-70), which causes abnormal thymic T cell selection and survival of autoreactive clones. Although the resulting clinical and pathologic abnormalities are clearly T cell-dependent, macrophage and fibroblast cytokines such as IL-1 and TNF-alpha are required for full expression of the disease. The studies of Hata et al. raise the intriguing possibility that traditional proinflammatory cytokine networks represent common effector mechanisms in inflammatory joint diseases such as rheumatoid arthritis. Hence, effective therapeutic interventions can target either unique etiologic pathways related to adaptive immune responses or shared terminal mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.