ArticleJournal of molecular neuroscience : MN2004
NAP mechanisms of neuroprotection.
Article in Journal of molecular neuroscience : MN, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium.Antioxidants (Basel, Switzerland) · 2022Article
- STOP Codon Mutations at Sites of Natural Caspase Cleavage Are Implicated in Autism and Alzheimer's Disease: The Case of ADNP.Frontiers in endocrinology · 2022Article
- Nap Interferes with Hypoxia-Inducible Factors and VEGF Expression in Retina of Diabetic Rats.Journal of molecular neuroscience : MN · 2017Article
- Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Review
- Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress.Brain research · 2016Review
- Autophagy has a key role in the pathophysiology of schizophrenia.Molecular psychiatry · 2015Article
- Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death.Journal of molecular neuroscience : MN · 2014Article
- NAP reduces murine microvascular endothelial cells proliferation induced by hyperglycemia.Journal of molecular neuroscience : MN · 2014Article
- The transcriptional regulator ADNP links the BAF (SWI/SNF) complexes with autism.American journal of medical genetics. Part C, Seminars in medical genetics · 2014Article
- NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy.Molecular psychiatry · 2013Article
- Tau and caspase 3 as targets for neuroprotection.International journal of Alzheimer's disease · 2012Article
- Article
- The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Article
- Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin.Molecular neurobiology · 2007Review
- Tubulin is the target binding site for NAP-related peptides: ADNF-9, D-NAP, and D-SAL.Journal of molecular neuroscience : MN · 2006Article
- PolyADP-ribosylation is involved in neurotrophic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures.Journal of molecular neuroscience : MN · 2005Article
- NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP).CNS drug reviews · 2005Review
- Parkinson's and Alzheimer's diseases: protein aggregations and neuroprotection.Journal of molecular neuroscience : MN · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-alpha, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.