ArticleMolecular and cellular biology2004
Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- MiR-513a promotes human erythroid differentiation by modulating c-Jun.FEBS open bio · 2026Article
- CK2β Regulates Hematopoietic Stem Cell Biology and Erythropoiesis.HemaSphere · 2023Article
- Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes.The Journal of clinical investigation · 2022Article
- ANTXR1 Regulates Erythroid Cell Proliferation and Differentiation through wnt/Disease markers · 2022Article
- Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4.iScience · 2021Article
- Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology.Current oncology reports · 2018Review
- Inhibition of MEK/ERK signalling pathway promotes erythroid differentiation and reduces HSCs engraftment in ex vivo expanded haematopoietic stem cells.Journal of cellular and molecular medicine · 2018Article
- Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition.The Journal of clinical investigation · 2017Article
- HEY1 functions are regulated by its phosphorylation at Ser-68.Bioscience reports · 2016Article
- Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors.PloS one · 2016Article
- Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis.Reproduction (Cambridge, England) · 2015Article
- Personalized Radioproteomics: Identification of a Protein Biomarker Signature for Preemptive Rescue by Tocopherol Succinate in CD34Journal of proteomics & bioinformatics · 2015Article
- The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis.The Journal of biological chemistry · 2014Article
- Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression.Blood · 2014Article
- GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis.Molecular and cellular biology · 2012Article
- Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.The Journal of biological chemistry · 2012Article
- The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.BMC molecular biology · 2012Article
- P. falciparum modulates erythroblast cell gene expression in signaling and erythrocyte production pathways.PloS one · 2011Article
- Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling.PloS one · 2011Article
- Article
Corrections and comments
- Erratum issuedErratum for Elagib et al., Jun Blockade of Erythropoiesis: Role for Repression of GATA-1 by HERP2.2015 · Shanmugasundaram, Ganapathy [Corrected to Ganapathy-Kanniappan, Shanmugasundaram]
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Although Jun upregulation and activation have been established as critical to oncogenesis, the relevant downstream pathways remain incompletely characterized. In this study, we found that c-Jun blocks erythroid differentiation in primary human hematopoietic progenitors and, correspondingly, that Jun factors block transcriptional activation by GATA-1, the central regulator of erythroid differentiation. Mutagenesis of c-Jun suggested that its repression of GATA-1 occurs through a transcriptional mechanism involving activation of downstream genes. We identified the hairy-enhancer-of-split-related factor HERP2 as a novel gene upregulated by c-Jun. HERP2 showed physical interaction with GATA-1 and repressed GATA-1 transcriptional activation. Furthermore, transduction of HERP2 into primary human hematopoietic progenitors inhibited erythroid differentiation. These results thus define a novel regulatory pathway linking the transcription factors c-Jun, HERP2, and GATA-1. Furthermore, these results establish a connection between the Notch signaling pathway, of which the HERP factors are a critical component, and the GATA family, which participates in programming of cellular differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.