ArticleMolecular and cellular biology2004
Cross-regulation among the polycomb group genes in Drosophila melanogaster.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Polycomb repression works without Siesta, theScience advances · 2026Article
- Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation.PLoS genetics · 2019Article
- Critical genomic regulation mediated by Enhancer of Polycomb.Current genetics · 2018Review
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Stuxnet Facilitates the Degradation of Polycomb Protein during Development.Developmental cell · 2016Article
- Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila.Open biology · 2014Review
- Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains.Genetics · 2009Article
- CHD3 proteins and polycomb group proteins antagonistically determine cell identity in Arabidopsis.PLoS genetics · 2009Article
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.PloS one · 2009Article
- Su(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activation.PloS one · 2009Article
- In vivo analysis of Drosophila SU(Z)12 function.Molecular genetics and genomics : MGG · 2008Article
- MicroRNAs in the Drosophila bithorax complex.Genes & development · 2008Article
- PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.Oncogene · 2007Article
- Dynamic regulatory interactions of Polycomb group genes: MEDEA autoregulation is required for imprinted gene expression in Arabidopsis.Genes & development · 2006Article
- Chromatin architectural proteins.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Genes of the Polycomb group in Drosophila melanogaster function as long-term transcriptional repressors. A few members of the group encode proteins found in two evolutionarily conserved chromatin complexes, Polycomb repressive complex 1 (PRC1) and the ESC-E(Z) complex. The majority of the group, lacking clear biochemical functions, might be indirect regulators. The transcript levels of seven Polycomb group genes were assayed in embryos mutant for various other genes in the family. Three Polycomb group genes were identified as upstream positive regulators of the core components of PRC1. There is also negative feedback regulation of some PRC1 core components by other PRC1 genes. Finally, there is positive regulation of PRC1 components by the ESC-E(Z) complex. These multiple pathways of cross-regulation help to explain the large size of the Polycomb group family of genes, but they complicate the genetic analysis of any single member.
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